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Natural products are an unsurpassed source of chemical diversity and an ideal starting point for any screening program for pharmacologically active small molecules. Historically, natural products have been the most successful source of new drugs. The SCREEN-WELL Natural Product library offers over 500 isolated natural compounds of known structure and includes many compounds from ethnopharmacology. Compounds are provided in solution in DMSO. Individual compounds or subsets can be resupplied in gram quantities. Contents: 502 compounds including compounds from the following classes of products: Terpenoids, Peptolides, Flavones, Coumarins, Alkaloids, Macrolides, Isoflavones, Synthetic derivates and many more. Application: HTS. Use/Stability: Stable for at least one year from the date of receipt when stored at -80°C. Long Term Storage: -80°C
DiscoveryProbe™ Autophagy Compound Library Plus is a unique collection of 837 autophagy-related compounds for autophagy research. Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation. Other sizes are also available. Please inqury us for quote.
The SCREEN-WELL Ion Channel Ligand Library contains 70 ion channel blockers and openers for use in characterizing and identifying ion channels in individual cells or tissue. Long Term Storage: -80°C. Applications: HTS .
The SCREEN-WELL Cancer Library is a collection of 275 compounds that can be used for cancer inhibitor screening and assay development. The library contains small molecules affecting mTOR, aurora kinases, tyrosine kinases, PI3K, and HDAC, as well as many structurally and mechanistically different compound classes. This library is an essential tool for cancer inhibitor screening and drug development. The compounds are dissolved in DMSO at 10 mM and aliquoted into 96-well deep-well plates at 100 µL per well. Long Term Storage: -80°C. Applications: HTS .
The SCREEN-WELL REDOX library contains 83 compounds with defined prooxidant or antioxidant activity. Compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates at 100 or 500µl per well.A variety of structurally and mechanistically different compound classes are included such as hydroperoxides, polyphenolics, metal chelators, thiols, thiol traps, radical scavengers, lazaroids and glutathione modulators as well as small molecule enzyme mimetics for SOD and glutathione peroxidase. The library is a useful tool for studying the roles of pro- and antioxidant molecules in cells as well as for use in in vitro applications. Long Term Storage: -80°C. Applications: HTS .
The Serotonergic Ligands Plate contains 79 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Serotonergic Ligands plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 680 ligands. Long Term Storage: -80°C. Applications: HTS .
A QUANTIZYME Assay System. The MMP-8 Colorimetric Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-8 (MMP-8, neutrophil collagenase, collagenase-2) using a thiopeptide as a chromogenic substrate. The assays are performed in a convenient 96-well plate format. Also included are active enzyme, a prototypic control inhibitor (NNGH), and a detailed instruction booklet. Alternative name: Neutrophil collagenase, Collagenase 2. Applications: Colorimetric detection, HTS Activity assay.
The Opioid and Sigma Ligands Plate contains 74 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Opioid and Sigma Ligands plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 650 ligands. Long Term Storage: -80°C. Applications: HTS .
The Histaminergic and Melatonin Ligands Plate contains 41 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Histaminergic and Melatonin Ligands plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 680 ligands. Long Term Storage: -80°C. Applications: HTS .
The SCREEN-WELL Purinergic and Adenosine Ligands Plate contains 72 CNS receptor ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Purinergic and Adenosine Ligands Plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 650 ligands. Long Term Storage: -80°C. Applications: HTS .
α-Dendrotoxin is isolated from Dendroaspis angusticeps snake venom, by modification of the procedures of Harvey and Benishin and purified to homogeneity. α-Dendrotoxin blocks Kv1.1 and Kv1.2 channels (IC50= 0.4 to 4 and 1.1 to 12 nM in oocytes respectively, with higher values for mammalian cells). In addition, the toxin was shown to block also Kv1.6 (IC50= 9-25 nM). Purity: ≥98% (HPLC). Solubility: Soluble in any aqueous buffer. Please centrifuge all product preparations at 10000 x g for 5 minutes before reconstitution. Long Term Storage: -20°C.
A cell-permeable and specific inhibitor of alkaline ceramidase, which can raise intracellular ceramide levels by blocking the hydrolysis of ceramide to sphingosine and free fatty acid. Enhances the apoptotic response to ionizing radiation by enhancing the ceramide signal. Alternative name: (1S,2R-D-erythro-2-N-Myristoylamino)-1-phenyl-1-propanol. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). Long Term Storage: -20°C.
The GABAergic Ligands library contains 56 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein-coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The GABAergics Ligands plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 650 CNS receptor ligands. Long Term Storage: -80°C. Applications: HTS .
The SCREEN-WELL Orphan ligand library contains 84 compounds with defined, putative, potential or speculative biological activity but whose protein binding partners have not been identified. Ligands are supplied dissolved in biocompatible solvents at 10mM and aliquoted into a deep-well plate at 500µl per well. The library is a rich source of ligands for receptor de-orphaning. Includes the following classes of ligands: Trace Amines, Neurotransmitter Metabolites, Endogenous β-carbolines, Urinary Metabolites, Nicotine Congeners, D-Amino Acids. Receptors for endogenous trace amines have been deorphanized. Endogenous β-carbolines have been shown to display varied biological effects such as hallucinations, hypotension and others. Nicotine congeners such as nornicotine are biologically active and may act at novel nicotinic receptor subtypes. Long Term Storage: -80°C. Applications: HTS .
Medchem Express / D-erythro-MAPP / 5mg / 761738490 / HY-137422 / / 143492-38-0 / MFCD01076527 / 361.570 / C23H39NO2