Chromatography

Pushing the Limits of Detection Further

Pushing the Limits of Detection Further

The Fisher Chemical™ portfolio offers more than 800 high-purity solvents formulated to suit applications for liquid chromatography/mass spectrometry (LC/MS), high-performance liquid chromatography (HPLC), gas chromatography (GC), and spectrometry. Our solvents are manufactured in ISO 9001 certified facilities and undergo rigorous quality assurance testing to bring you the lot-to-lot and bottle-to-bottle consistency you rely on.

Solvents Application Guide

Learn more about our portfolio of over 800 high-purity solvents.

Download the Solvents Application Guide (PDF, 9.3MB)


Optima LC/MS Grade Solvents

Optima LC/MS Grade Solvents

Fisher Chemical™ Optima™ LC/MS solvents are tested using advanced UHPLC technology coupled with PDA detection optics. Each lot of Optima LC/MS solvents is screened in the 200 to 400 nm wavelength range for UV-absorbing contaminants that could create interferences. Optima LC/MS solvents are formulated for UHPLC/UV methods that require mobile phases free of UV-absorbing 2 interference.

Optima LC/MS Grade Mobile Phase Blends

These ready-to-use aqueous and organic mobile phase blends are pre-blended with Optima LC/MS formic acid or trifluoroacetic acid for UHPLC/UV and UHPLC/MS applications. They’re filtered to 0.1μm for use with UHPLC separation and produced in ISO 9001-certified facilities to ensure lot-to-lot consistency.


Optima LC/MS Grade Solvents

Optima Grade Solvents

Fisher Chemical Optima solvents are manufactured for use in applications for which performance is essential: HPLC, GC, spectrophotometry, environmental testing, and more.

  • Screened for fluorescing and UV-absorbing contaminants
  • Meet ACS specifications
  • Certificates of analysis available online and by scanning the QR code on the label
  • Chromatograms available on request

Gas Chromatography

Gas Chromatography

GC Headspace Grade Solvents

Mitigate the risk of interfering contaminants with Fisher Chemical GC Headspace grade solvents, providing clean solvent baselines with no extraneous peaks and reliable results.

GC Resolv Solvents

Count on Fisher Chemical GC Resolv™ solvents for high purity and lot-to-lot consistency for your gas chromatography applications.


HPLC Grade Solvents and Blends

HPLC Grade Solvents and Blends

Manufactured specially for use with high-performance liquid chromatography instruments, Fisher Chemical HPLC grade solvents and blends meet ACS specifications and are submicron filtered.

HPLC Grade Mobile Phase Blends

Fisher Chemical HPLC mobile phase blends meet HPLC specifications and provide a consistent concentration of formic acid or trifluoroacetic acid with a very low LC/UV background.


These products are intended for research only.