Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme that plays an important role in numerous, cellular functions. APE is responsible for repairing abasic sites in DNA and in regulating the redox state of other proteins that play roles in oxidative signaling, transcription factor regulation (Fos, Jun, NF-kB, Myb, HIF-1 alpha, CREB, Pax), cell cycle control (p53), and apoptosis. The most common form of DNA damage is the creation of abasic sites which are brought about through spontaneous loss or oxidative DNA damage, through chemically initiated hydrolysis (chemotherapy), ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA glycosylases. APE is differentially expressed during development and in different tissues. This protein has diverse subcellular localization patterns which support the possibility of its interaction with numerous, other cellular proteins in addition to DNA repair within the nucleus. Regulation of APE by phosphorylation is mediated, at least in part, by casein kinase II. Increases in APE message and protein levels are observed upon the reintroduction of oxygen to hypoxic cells, and in some malignant tissue relative to normal tissue. Decreases in APE expression have been associated with the induction of cellular apoptosis.
Invitrogen
APE1 Mouse anti-Canine, Human, Mouse, Non-human primate, Rat, Clone: 13B 8E5C2, Invitrogen™ APE1 Mouse anti-Canine, Human, Mouse, Non-human primate, Rat, Clone: 13B 8E5C2, Invitrogen™Cat # MA1440
100 µL
Invitrogen
APE1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ APE1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™Cat # PIPA529157
100 µL
Invitrogen
APE1 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™ APE1 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™Cat # PIPA517233
100 µL
Invitrogen
APE1 Rabbit anti-Human, Polyclonal, Invitrogen™ APE1 Rabbit anti-Human, Polyclonal, Invitrogen™Cat # PIPA580342
100 µL
Invitrogen
APE1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™ APE1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™Cat # PIPA585228
100 µL
Invitrogen
APE1 Goat anti-Human, Polyclonal, Invitrogen™ APE1 Goat anti-Human, Polyclonal, Invitrogen™Cat # 01-674-591
100 µg
Invitrogen
APE1 Rabbit anti-Human, Mouse, Non-human primate, Rabbit, Rat, Polyclonal, Invitrogen™ APE1 Rabbit anti-Human, Mouse, Non-human primate, Rabbit, Rat, Polyclonal, Invitrogen™Cat # APPA6500
100 µL
Invitrogen
APE1 Rabbit anti-Human, Polyclonal, Invitrogen™ APE1 Rabbit anti-Human, Polyclonal, Invitrogen™Cat # PIPA512471
400 µL
Invitrogen
APE1 Rabbit anti-Human, Polyclonal, Invitrogen™ APE1 Rabbit anti-Human, Polyclonal, Invitrogen™Cat # PA129465
100 µg
Invitrogen
APE1 Rabbit anti-Human, Polyclonal, Invitrogen™ APE1 Rabbit anti-Human, Polyclonal, Invitrogen™Cat # 01-675-781
100 µg
Invitrogen
APE1 Rabbit anti-Bovine, Equine, Guinea Pig, Mouse, Rabbit, Rat, Polyclonal, Invitrogen™ APE1 Rabbit anti-Bovine, Equine, Guinea Pig, Mouse, Rabbit, Rat, Polyclonal, Invitrogen™Cat # PIPA568800
100 µL
Invitrogen
APE1 Mouse anti-Human, Mouse, Clone: 2104, Invitrogen™ APE1 Mouse anti-Human, Mouse, Clone: 2104, Invitrogen™Cat # PIMA531586
100 µL
Invitrogen
APE1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ APE1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™Cat # PIPA586388
100 µL
Invitrogen
APE1 Rabbit anti-Human, Polyclonal, Invitrogen™ APE1 Rabbit anti-Human, Polyclonal, Invitrogen™Cat # PIPA588088
100 µL
Invitrogen
APE1 Rabbit anti-Human, Mouse, Rat, Unconjugated, Clone: ARC0556, Invitrogen™ APE1 Rabbit anti-Human, Mouse, Rat, Unconjugated, Clone: ARC0556, Invitrogen™Cat # PIMA535087
100 µL
Invitrogen
APE1 Rabbit anti-Human, Human, Polyclonal, Invitrogen™ APE1 Rabbit anti-Human, Human, Polyclonal, Invitrogen™Cat # PIPA5116972
100 µL
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