Test
Armenian Hamster Monoclonal Antibody
Content And Storage | Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to the dye under optimum conditions and unreacted dye was removed. |
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Target Species | Human,Mouse |
Host Species | Armenian Hamster |
Conjugate | Alexa Fluor 488 |
Applications | Flow Cytometry |
Form | Liquid |
Isotype | IgG |
Concentration | 0.2 mg/mL |
Antigen | ICOS (CD278) |
Regulatory Status | RUO |
Purification Method | Affinity Chromatography |
Gene Alias | ICOS; AILIM; H4; Inducible T-cell costimulator; CVID1; Ly115 |
Gene ID (Entrez) | 29851 |
Formulation | Aqueous buffered solution containing ≤0.09% sodium azide. |
Immunogen | Mouse D10.G4.1 T-cell clone |
Classification | Monoclonal |
Primary or Secondary | Primary |
Clone | C398.4A |
Human CD28 is composed of four exons encoding a protein of 220 amino acids that is expressed on the cell surface as a glycosylated, disulfide-linked homodimer of 44 kDa. Members of the CD28 family share a number of common features. These receptors consist of paired V-set immunoglobulin superfamily (IgSF) domains attached to single transmembrane domains and cytoplasmic domains that contain critical signaling motifs. The CD28 and CTLA4 ligands, CD80 and CD86, consist of single V-set and C1-set IgSF domains. The interaction of these costimulatory receptors with ligands is mediated through the MYPPPY motif within the receptor V-set domains. CD28 is expressed constitutively on almost all human CD4 T cells and approximately 50% of CD8 T cells. CD28 costimulation has diverse effects on T cell function, including biochemical events at the immunological synapse, downstream phosphorylation and other post-translational modifications, transcriptional changes, and cytoskeletal remodeling.
NC2964690 TREMELIMUMAB ANTI-CTLA-4 1MG
Recombinant protein. Human CD152 aa 36-161 is untagged. Binds to human CD80. Source HEK 293 cells. Lyophilized. Contains PBS. CD152 Cytotoxic T-lymphocyte-associated protein 4 CTLA-4 is an inhibitory receptor belonging to the CD28 immunoglobulin subfamily, expressed primarily by T cells. Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4, resulting in a costimulatory or a co-inhibitory response, respectively. Because of its dampening effect, CTLA-4 is a crucial regulator of T cell homeostasis and self-tolerance. While CD28 promotes T cell activation and proliferation, CTLA-4 is reported to dampen T cell responses through a variety of mechanisms. Prior to activation, conventional T cells Tconv express low levels of CTLA-4, predominantly in intracellular compartments. Upon activation, CTLA-4 expression is upregulated and becomes increasingly detectable on the cell surface.
Hamster Anti Mouse CD28 Biotinylated
Hamster Anti Mouse CTLA-4; (CD152)
CD28, Hamster Anti-Mouse, FITC, CD28 Antibody, FITC, Clone NYRmCD28. Type Hamster Anti Mouse Monoclonal.
CD28, Hamster Anti-Mouse, CD28 Antibody, Type Hamster Anti Mouse Monoclonal. Clone NYRmCD28.
NC2872582 H CTLA4/CD152 CONC LVRS 200UL