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  5. Tocris™ Rhein

Tocris™ Rhein

FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3

$185.60 - $770.24

Specifications

Molecular Formula C15H8O6
Formula Weight 284.22
Product Type Inhibitor
Purity 98%
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
68-671-0
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Tocris™
6867/10 		10 mg
Each for $185.60
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68-675-0
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Tocris™
6867/50 		50 mg
Each for $770.24
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Description

Description

Rhein is a FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 μM; Ki = 1.8 μM). Competitively binds enzyme at active site preventing binding of N6-methyladenosine (m6A) substrate and resulting in accumulation of DNA damage in cells. Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 μM, respectively). Sensitizes glioblastoma cells to alkylating agents. Active in vivo.
Specifications

Specifications

C15H8O6
284.22
Inhibitor
98%
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

SDS
Documents

Documents

Product Certifications
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