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Tocris™ Rhein

FTO (mRNA N6-methyladenine demethylase) inhibitor; also inhibits ALKBH2 and ALKBH3

Supplier:  Tocris™ 6867/50

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Catalog No. 68-675-0


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Description

Description

Rhein is a FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 μM; Ki = 1.8 μM). Competitively binds enzyme at active site preventing binding of N6-methyladenosine (m6A) substrate and resulting in accumulation of DNA damage in cells. Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 μM, respectively). Sensitizes glioblastoma cells to alkylating agents. Active in vivo.
Specifications

Specifications

50 mg
284.22
98%
C15H8O6
Inhibitor
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Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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