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Tocris Bioscience™ PS 1145 dihydrochloride
Selective IKK inhibitor; orally active
$286.52 - $1177.40
Specifications
| Purity | >98% |
|---|---|
| Product Type | PS 1145 dihydrochloride |
| Molecular Weight (g/mol) | 395.67 |
| Inhibitors | PS 1145 dihydrochloride |
Description
Selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.Specifications
| >98% | |
| PS 1145 dihydrochloride | |
| 395.67 | |
| PS 1145 dihydrochloride |
For Research Use Only
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