Tocris Bioscience™ PS 1145 dihydrochloride

Selective IKK inhibitor; orally active

Supplier:  Tocris Bioscience™ 4569/10

Catalog No. 45-691-0

Description

PS 1145 dihydrochloride is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.

Specifications

• Purity: >98%
• Product Type: PS 1145 dihydrochloride
• Inhibitors: PS 1145 dihydrochloride

• Quantity: 10 mg
• Molecular Weight (g/mol): 395.67

For Research Use Only