Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Tocris Bioscience™ GW 280264X
Potent ADAM10 and ADAM17 inhibitor
$396.00 - $1661.00
Specifications
| Chemical Name or Material | Phenylmethyl N-[(5 S)-5-[[(2 R,3 S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate |
|---|---|
| CAS | 866924-39-2 |
| Target | Synthetic Metalloprotease Inhibitors |
| Molecular Formula | C28H41N5O6S |
| Purity | 0.98 |
Description
GW 280264X is a potent ADAM (A Disintegrin and Metalloproteinase) 17 and ADAM10 inhibitor (IC50 values of 8 nM and 11.5 nM, respectively). It inhibits constitutive and PMA-inducible CX3CL1 shedding and increases adhesive properties in CX3CL1 transfected cells (IC50 = 1 μM in COS-7 and ECV-304 cells). GW 280264X treatment in mice significantly improves functional recovery after spinal cord injury.Specifications
| Phenylmethyl N-[(5 S)-5-[[(2 R,3 S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate | |
| Synthetic Metalloprotease Inhibitors | |
| 0.98 |
| 866924-39-2 | |
| C28H41N5O6S |
Safety and Handling
Recommended Storage : Store at -20°C
Spot an opportunity for improvement?
Provide Content Correction
Provide Content Correction
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Product Title