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Tocris Bioscience™ GW 280264X
Potent ADAM10 and ADAM17 inhibitor
Supplier: Tocris Bioscience™ 7030/10
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Description
GW 280264X is a potent ADAM (A Disintegrin and Metalloproteinase) 17 and ADAM10 inhibitor (IC50 values of 8 nM and 11.5 nM, respectively). It inhibits constitutive and PMA-inducible CX3CL1 shedding and increases adhesive properties in CX3CL1 transfected cells (IC50 = 1 μM in COS-7 and ECV-304 cells). GW 280264X treatment in mice significantly improves functional recovery after spinal cord injury.Specifications
| Phenylmethyl N-[(5 S)-5-[[(2 R,3 S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate | |
| 10 mg | |
| C28H41N5O6S |
| 866924-39-2 | |
| Synthetic Metalloprotease Inhibitors | |
| 0.98 |
Safety and Handling
Recommended Storage : Store at -20°C
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