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Tocris Bioscience™ CRID3 sodium salt
Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
Supplier: Tocris Bioscience™ 5479/10
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Description
CRID3 sodium salt is a potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC50 values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.Specifications
| 98% | |
| 426.46 | |
| 10 mg |
| CRID3 sodium salt | |
| CRID3 sodium salt |
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