Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 amino acids that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.
Invitrogen
p23 Mouse anti-Chicken, Guinea Pig, Human, Mouse, Rabbit, Rat, Clone: JJ3, Invitrogen™ p23 Mouse anti-Chicken, Guinea Pig, Human, Mouse, Rabbit, Rat, Clone: JJ3, Invitrogen™Cat # MA3414
100 µL
Invitrogen
p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™Cat # PIPA529547
100 µL
Invitrogen
p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™Cat # PIPA583434
100 µL
Invitrogen
p23 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™ p23 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™Cat # PIPA528476
100 µL
Invitrogen
p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™Cat # PIPA583435
100 µL
Invitrogen
p23 Rabbit anti-Human, Polyclonal, Invitrogen™ p23 Rabbit anti-Human, Polyclonal, Invitrogen™Cat # PIPA580954
100 µL
Invitrogen
p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™Cat # PIPA5102730
100 µL
Invitrogen
p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™Cat # PIPA586522
100 µL
Invitrogen
p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ p23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™Cat # PIPA592396
100 µL
Invitrogen
p23 Rabbit anti-Human, Human, Mouse, Rat, Clone: ARC1986, Invitrogen™ p23 Rabbit anti-Human, Human, Mouse, Rat, Clone: ARC1986, Invitrogen™Cat # PIMA538139
100 µL
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