HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.
Invitrogen
HIF-1 beta Mouse anti-Human, Mouse, Non-human primate, Rat, Clone: 2B10, Invitrogen™ HIF-1 beta Mouse anti-Human, Mouse, Non-human primate, Rat, Clone: 2B10, Invitrogen™Cat # MA1515
100 µL
Invitrogen
HIF-1 beta Rabbit anti-Human, Polyclonal, Invitrogen™ HIF-1 beta Rabbit anti-Human, Polyclonal, Invitrogen™Cat # PIPA581967
100 µL
Invitrogen
HIF-1 beta Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™ HIF-1 beta Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™Cat # PIPA585521
100 µL
Invitrogen
HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, DyLight™ 650, Clone: H1beta234, Invitrogen™ HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, DyLight™ 650, Clone: H1beta234, Invitrogen™Cat # PIMA516012
100 µL
Invitrogen
HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, Biotin, Clone: H1beta234, Invitrogen™ HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, Biotin, Clone: H1beta234, Invitrogen™Cat # PIMA516011
100 µL
Invitrogen
HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, HRP, Clone: H1beta234, Invitrogen™ HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, HRP, Clone: H1beta234, Invitrogen™Cat # PIMA516014
100 µL
Invitrogen
HIF-1 beta Rabbit anti-Bovine, Canine, Equine, Guinea Pig, Human, Mouse, Ovine, Rabbit, Rat, Zebrafish, Polyclonal, Invitrogen™ HIF-1 beta Rabbit anti-Bovine, Canine, Equine, Guinea Pig, Human, Mouse, Ovine, Rabbit, Rat, Zebrafish, Polyclonal, Invitrogen™Cat # PIPA568507
100 µL
Invitrogen
HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, DyLight™ 550, Clone: H1beta234, Invitrogen™ HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, DyLight™ 550, Clone: H1beta234, Invitrogen™Cat # PIMA516015
100 µL
Invitrogen
HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, DyLight™ 488, Clone: H1beta234, Invitrogen™ HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, DyLight™ 488, Clone: H1beta234, Invitrogen™Cat # PIMA516013
100 µL
Invitrogen
HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, Clone: H1beta234, Invitrogen™ HIF-1 beta Mouse anti-Bovine, Ferret, Human, Mouse, Non-human primate, Ovine, Rat, Clone: H1beta234, Invitrogen™Cat # AMPA6512
100 µL
Invitrogen
HIF-1 beta Rabbit anti-Bovine, Ferret, Human, Mouse, Ovine, Rat, Polyclonal, Invitrogen™ HIF-1 beta Rabbit anti-Bovine, Ferret, Human, Mouse, Ovine, Rat, Polyclonal, Invitrogen™Cat # APSA6508
100 µL
Invitrogen
HIF-1 beta Rabbit anti-Human, Unconjugated, Clone: ARC0010, Invitrogen™ HIF-1 beta Rabbit anti-Human, Unconjugated, Clone: ARC0010, Invitrogen™Cat # PIMA535289
100 µL
Cat # PIMA533114
100 µL
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