TCI DualSeal Bottles: Two Layers for Safety and Protection

Some chemicals, especially those used in organic synthesis, are sensitive to air and moisture and react — sometimes violently — when exposed to oxygen or water. In 2017, TCI introduced their patented DualSeal reagent bottles to provide an air-free environment for these highly reactive reagents, making it possible to handle them in a safe and effective manner.

The blue outer cap has an inner Teflon layer that helps maintain an air-tight seal, even when the inner septum has been pierced. The colorless inner cap septum has two layers of rubber and one of highly chemical-resistant PTFE (polytetrafluoroethylene). The septum is large enough for easy access and self-seals after being pierced to maintain conditions inside the container, even after repeated use. The DualSeal cap is attached or removed normally. For everyday use, remove just the outer cap, and remove (unscrew) the inner cap when you dispose of the bottle.

Steps for Safe Usage

  • Clamp or otherwise secure the reagent bottle before opening
  • Carefully unscrew the outer cap and place it near the bottle
  • Insert a needle into an inert gas line (Ar, N2) through the Teflon seal
  • Retrieve the amount of reagent needed
  • Purge the headspace with inert gas and remove the needle
  • Replace the outer cap and screw tightly into place (do not place tape or other material between the caps — it can significantly reduce seal quality)
  • Unclamp the bottle and return it to storage 

To remove the inner cap for disposal:

  • Clamp or otherwise secure the bottle and remove the outer cap
  • Grasp the inner cap and remove it; use pliers as needed
  • Avoid spillage; be aware that residual chemical may exist on the underside of the cap
  • Dispose of caps and bottles cautiously after removing any remaining chemical 

TCI Reagents Packaged in DualSeal Containers

ReactionChemicalCat. No.


Reductions



Lithium Aluminum Hydride (10% in Tetrahydrofuran)
Lithium Borohydride (ca. 4 mol/L in Tetrahydrofuran)
Triethoxy[5,5,6,6,7,7,7-heptafluoro-4,4-bis(trifluoromethyl)heptyl]silane 90+%
Lithium Triethylborohydride (ca. 12% in Tetrahydrofuran)
Sodium Bis(2-methoxyethoxy)aluminum Dihydride (70% in Toluene)
Triisopropylsilane 98.0+%
L0170
L0186
T3246
L0190
S0467
T1533

Bases

Sodium Methoxide (ca. 5 mol/L in Methanol)
Potassium tert-Butoxide (12% in Tetrahydrofuran)
Sodium Bis(trimethylsilyl)amide (contains 2-Methyl-2-butene) (38% in Tetrahydrofuran)
Lithium Bis(trimethylsilyl)amide (ca. 26% in Tetrahydrofuran)
S0486
P1619
H0894
H0915
LithiationLithium Chloride (2.3% in Tetrahydrofuran)H0915

Lewis Acids
Boron Trifluoride, Ethyl Ether Complex 98+%
Titanium (IV) Chloride (14% in Dichloromethane)
Zinc Chloride (ca. 7% in Tetrahydrofuran)
B0527
T2052
Z0019
Nucleophiles
Diethylzinc (ca. 17% in Hexane)
Diethylzinc (ca. 15% in Toluene)
D3214
D3902
Solvent1-Butoxy-2-propanol 96+%B0864
Protection
N-Trimethylsilylimidazole 98+%
Bromotrimethylsilane 95+%
T0585
B1087
CatalysisTetraisopropyl OrthotitanateT0133

Visit fishersci.com/TCIpromo or fishersci.ca/TCIpromo to learn how you can get one TCI product at no additional cost when you buy two. (Excludes healthcare customers.)

tci-dualseal-reagents-d-408-1498

Content provided by:

TCI-1498
Reference