Acyl Halides
Acyl Halides
AdipoGen Physil chloride
Chemical. CAS 114341-14-9. Formula C14H10ClNO3S. MW 307.75. Synthetic. It is known that phenol and p-cresol are promoters of skin tumors and also urinary excretion of phenol and p-cresol is increased by exposure to benzene, which has hemopoietic toxicity, and toluene, respectively. Therefore, the determination of phenol and p-cresol is important in clinical chemistry and toxicology. Because phenol and p-cresol are present in urine as sulfate or glucuronide conjugates, they are hydrolyzed enzymatically or with acid, followed by distillation or extraction with organic solvent prior to measurement by GC or HPLC. However, these GC and HPLC methods require relatively large sample volumes more than 1 ml because of their insufficient sensitivities for measuring small amounts of phenol and p-cresol. The application of fluorescent labeling techniques to HPLC result in a sensitive and selective method.
AdipoGen Physil chloride
Chemical. CAS 114341-14-9. Formula C14H10ClNO3S. MW 307.75. Synthetic. It is known that phenol and p-cresol are promoters of skin tumors and also urinary excretion of phenol and p-cresol is increased by exposure to benzene, which has hemopoietic toxicity, and toluene, respectively. Therefore, the determination of phenol and p-cresol is important in clinical chemistry and toxicology. Because phenol and p-cresol are present in urine as sulfate or glucuronide conjugates, they are hydrolyzed enzymatically or with acid, followed by distillation or extraction with organic solvent prior to measurement by GC or HPLC. However, these GC and HPLC methods require relatively large sample volumes more than 1 ml because of their insufficient sensitivities for measuring small amounts of phenol and p-cresol. The application of fluorescent labeling techniques to HPLC result in a sensitive and selective method.