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Trimethyl phosphonoacetate, 98%, Thermo Scientific Chemicals
Description
Trimethyl phosphonoacetate is used in the preparation of sarin A by intramolecular Mannich-type reactions. It is involved in the Horner-Wadsworth-Emmons olefination with aldehydes and ketones to give acrylic esters. It is also involved in oxa-Michael reactions, prenylation of oxindoles and heterocyclization reactions.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Trimethyl phosphonoacetate is used in the preparation of sarin A by intramolecular Mannich-type reactions. It is involved in the Horner-Wadsworth-Emmons olefination with aldehydes and ketones to give acrylic esters. It is also involved in oxa-Michael reactions, prenylation of oxindoles and heterocyclization reactions.
Solubility
Slightly miscible with water.
Notes
Incompatible with strong oxidizing agents.
Specifications
| Density | 1.263 |
| Boiling Point | 119°C to 120°C (1 mmHg) |
| Flash Point | 70°C (158°F) |
| Refractive Index | 1.437 |
| Quantity | 100 g |
| Beilstein | 1865177 |
| Solubility Information | Slightly miscible with water. |
| Formula Weight | 182.11 |
| Percent Purity | 98% |
| Chemical Name or Material | Trimethyl phosphonoacetate |
Safety and Handling
| Hazard Category | Warning |
| Hazard Statement | GHS H Statement H315-H319-H335-H227 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid. |
| Precautionary Statement | GHS P Statement P210-P261-P280-P305+P351+P338-P405-P501a Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapors/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. |
| EINECSNumber | 227-663-0 |
| TSCA | Yes |
| Recommended Storage | Ambient temperatures |
RUO – Research Use Only
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