tert-Butyl carbazate, 98+%, Thermo Scientific Chemicals

Description

tert-Butyl carbazate is used in a palladium-catalyzed cross-coupling with vinyl halides to prepare N-Boc-N-alkenylhydrazines. It is utilized in solid phase peptide synthesis and in the optical purity determination of alfa-amino aldehyde. It reacts with aldehydes to get hydrazones, which finds application as an intermediate in the synthesis of HIV-1 protease inhibitors. In addition to this, it is used as a starting material for the preparation of BOC-azide, sulfonic and carboxylic hydrazides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
tert-Butyl carbazate is used in a palladium-catalyzed cross-coupling with vinyl halides to prepare N-Boc-N-alkenylhydrazines. It is utilized in solid phase peptide synthesis and in the optical purity determination of alfa-amino aldehyde. It reacts with aldehydes to get hydrazones, which finds application as an intermediate in the synthesis of HIV-1 protease inhibitors. In addition to this, it is used as a starting material for the preparation of BOC-azide, sulfonic and carboxylic hydrazides.

Solubility
Soluble in ethanol and methanol.

Notes
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

Specifications

Chemical Identifiers

• CAS: 870-46-2
• Molecular Formula: C5H12N2O2
• Molecular Weight (g/mol): 132.163
• MDL Number: MFCD00007593
• InChI Key: DKACXUFSLUYRFU-UHFFFAOYSA-N
• Synonym: tert-butyl carbazate, tert-butyl hydrazinecarboxylate, t-butyl carbazate, hydrazinecarboxylic acid, 1,1-dimethylethyl ester, t-butylcarbazate, tert-butoxycarbonyl hydrazide, boc-hydrazide, boc-hydrazine, tert-butoxycarbonyl hydrazine, carbazic acid tert-butyl ester
• PubChem CID: 70091
• IUPAC Name: tert-butyl N-aminocarbamate
• SMILES: CC(C)(C)OC(=O)NN

• Melting Point: 37°C to 41°C
• Boiling Point: 63°C to 65°C (0.1 mmHg)
• Flash Point: 91°C (195°F)
• Quantity: 25 g
• UN Number: UN1325
• Beilstein: 1756967
• Sensitivity: Moisture sensitive
• Solubility Information: Soluble in ethanol and methanol.
• Formula Weight: 132.16
• Percent Purity: ≥98%
• Chemical Name or Material: tert-Butyl carbazate

Safety and Handling

Hazard Category	H228-H301+H311-H315-H319-H335
Hazard Statement	GHS H Statement H228 Flammable solid.
Precautionary Statement	P210-P240-P241-P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P361-P363-P370+P378q-P501c
DOTInformation	Hazard Class: 4.1; Packaging Group: II
EINECSNumber	212-795-3
TSCA	Yes
Recommended Storage	Keep cold

SDS

RUO – Research Use Only