Tamoxifen, 98%, Thermo Scientific Chemicals

Description

Tamoxifen (citofen, CAS # 10540-29-1) is an antineoplastic agent that has its effect through the estrogen receptors.

Inhibitor of protein kinase C and induces apoptosis in cancer cells. It is utilized in the study on lipopolysaccharide (LPS)-induced microglial activation to know its effect.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Tamoxifen is a tertiary aminobenzene that acts by competitively binding and antagonizing estrogen receptors to reduce DNA synthesis
• When estradiol cannot bind estrogen receptors, the DNA response element is not activated
• Tamoxifen upregulates the production of TGFb and slows tumor growth
• Tamoxifen inhibits the production of IGF-1, a stimulator of tumor growth

Application

• Tamoxifen may be useful in the study of tumorigenesis, growth, and inflammation
• It is suitable for in vitro experiments

Specifications

• Color: White
• Quantity: 1 g
• Merck Index: 14,9048
• Solubility Information: Insoluble in water; Soluble in methanol,ethanol,propanol or propylene glycol;Soluble in dimethyl sulfoxide,dichloromethane and ethanol; Insoluble in water.
• Formula Weight: 371.52
• Percent Purity: 98%
• Physical Form: Powder
• Chemical Name or Material: Tamoxifen

Safety and Handling

Hazard Category	H302-H350-H360FD-H362
Hazard Statement	GHS H Statement H350-H360-H362 May cause cancer. May damage fertility or the unborn child. May cause harm to breast-fed children.
Precautionary Statement	P201-P202-P260-P263-P264b-P270-P281-P301+P312-P308+P313-P330-P501c
EINECSNumber	234-118-0
RTECSNumber	KR5919600
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only