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  7. Tamibarotene, Thermo Scientific Chemicals

Tamibarotene, Thermo Scientific Chemicals

Catalog Number AAJ64028MF
Click to view available options
Quantity:
10 mg
50 mg
94497-51-5
C22H25NO3
351.45
MFCD00866188
MUTNCGKQJGXKEM-UHFFFAOYSA-N
tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202
108143
CHEBI:32181
4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12
94497-51-5
C22H25NO3
351.45
MFCD00866188
MUTNCGKQJGXKEM-UHFFFAOYSA-N
tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202
108143
CHEBI:32181
4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12

Description

A retinoic acid receptor → (RAR→) agonist

Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 ?M respectively).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively).

Solubility
Soluble to 50 mM in DMSO

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
TRUSTED_SUSTAINABILITY
Color White
Quantity 50 mg
Merck Index 14,9047
Solubility Information Soluble to 50 mM in DMSO
Formula Weight 351.44
Physical Form Solid
Chemical Name or Material Tamibarotene

Safety and Handling

RTECSNumber DH6940000
TSCA No
Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

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