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  7. SR 95531 hydrobromide, Tocris Bioscience™

SR 95531 hydrobromide, Tocris Bioscience™

Catalog Number 126250
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
104104-50-9
C15H18BrN3O3
368.231
GFZHNFOGCMEYTA-UHFFFAOYSA-N
gabazine, sr 95531 hydrobromide, gabazine hydrobromide,sr-95531, 1 6h-pyridazinebutanoic acid, 6-imino-3-4-methoxyphenyl-, monohydrobromide, 4-6-imino-3-4-methoxyphenyl pyridazin-1 6h-yl butanoic acid hydrobromide, 6-amino-5-methyl-3-4-methoxyphenyl-1-pyridaziniumbutyric acid br, 6-imino-3-4-methoxyphenyl-1 6h-pyridazinebutanoic acid hydrobromide, 6-imino-3-4-methoxyphenyl-1 6h-pyridazinebutanoic acid monohydrobromide, 1 6h-pyridazinebutanoicacid, 6-imino-3-4-methoxyphenyl-, hydrobromide 1:1, gabazine hydrobromide
107895
4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;hydrobromide
COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O.Br
This item is not returnable. View return policy
104104-50-9
C15H18BrN3O3
368.231
GFZHNFOGCMEYTA-UHFFFAOYSA-N
gabazine, sr 95531 hydrobromide, gabazine hydrobromide,sr-95531, 1 6h-pyridazinebutanoic acid, 6-imino-3-4-methoxyphenyl-, monohydrobromide, 4-6-imino-3-4-methoxyphenyl pyridazin-1 6h-yl butanoic acid hydrobromide, 6-amino-5-methyl-3-4-methoxyphenyl-1-pyridaziniumbutyric acid br, 6-imino-3-4-methoxyphenyl-1 6h-pyridazinebutanoic acid hydrobromide, 6-imino-3-4-methoxyphenyl-1 6h-pyridazinebutanoic acid monohydrobromide, 1 6h-pyridazinebutanoicacid, 6-imino-3-4-methoxyphenyl-, hydrobromide 1:1, gabazine hydrobromide
107895
4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;hydrobromide
COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O.Br

Description

Competitive and selective GABAA antagonist

SR 95531 hydrobromide is a selective, competitive GABAA receptor antagonist and allosteric inhibitor (IC50 = 200 nM). SR 95531 displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Unlike Bicuculline (Cat. No. 0130), SR 95531 selectively antagonizes GABA-induced Cl- currents with little action on Pentobarbitone -induced currents (Cat. No. 4579). SR 95531 can act as an agonist at high concentrations (>100 μM) and is a weak agonist at GABAA receptors with α1β2(Y157S)γ2L subunits. SR 95531 also acts as a competitive antagonist of recombinant glycine receptors and exhibits greater potency at glycine receptors containing β subunits.
Quantity 50 mg
Formula Weight 368.23
Percent Purity >98%
Chemical Name or Material SR 95531 hydrobromide

Safety and Handling

Recommended Storage Store at Room Temperature
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