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SHP-1 Recombinant Rabbit Monoclonal Antibody (SR41-02), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Supplier: Thermo Scientific MA531989
Description
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.![TRUSTED_SUSTAINABILITY](/content/dam/fishersci/glyphs/Sustain_Badge.png)
Specifications
SHP-1 | |
Monoclonal | |
1 mg/mL | |
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4 | |
P29350, P29351, P81718 | |
PTPN6 | |
Synthetic peptide within Human SHP1 aa 537-595 | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot | |
SR41-02 | |
Unconjugated | |
PTPN6 | |
70Z-SHP, EC 3.1.3.48, hcp, Hcph, hematopoietic cell phosphatase, hematopoietic cell protein-tyrosine phosphatase, HPTP1C, me, motheaten, protein tyrosine phosphatase, non-receptor type 6, protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, PTN6, Ptp1C, PTP-1C, Ptph6, PTPN6, PTPTY-42, SH2 phosphatase 1, SHP1, Shp-1, SHP-1L, SH-PTP1, Tyrosine-protein phosphatase non-receptor type 6 | |
Rabbit | |
Protein A | |
RUO | |
116689, 15170, 5777 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
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