Thermo Scientific™ Pierce™ Protein Precipitation Plates

Pierce Protein Precipitation Plates are used for protein processing via simple, rapid and automatable protein precipitation and removal of proteins from plasma, serum and other biological fluid samples alongside the Rapid Equilibrium Device (RED) for plasma protein-binding assays.

Catalog Number	Mfr. No.	Description
PI90036	Thermo Scientific™ 90036	Pierce™ Protein Precipitation Plates, 2 Plates
PI90037	Thermo Scientific™ 90037	Pierce™ Protein Precipitation Plates, 10 Plates

Description

Thermo Scientific Pierce Protein Precipitation Plates provide an easy, 96-well format for simple, rapid and automatable protein precipitation and filtration (purification) from plasma, serum and other biological fluid samples.

Pierce™ Protein Precipitation Plates are designed specifically for solvent-based precipitation of proteins and their subsequent removal from fluid samples. The plates are leak-free and retain organic solvent without dripping, even while mixing. The 2 mL well volume allows processing sample volumes of 15 to 400 μL per well, using the recommended precipitation conditions of 3:1 (v/v) solvent-to-serum ratio. The Protein Precipitation Plates are the ideal choice for downstream processing of plasma protein binding assay samples prepared with rapid equilibrium dialysis (RED) systems that are important for the pharmaceutical industry to perform plasma protein-binding assays, which comprise a critical step in drug development. Pierce Protein Precipitation Plates use a special graded filter system that retains precipitated protein particles without clogging, yet freely allows soluble (nonprecipitated) proteins to elute through the 0.2 μM cut-off membrane. This design maximizes protein removal and ensures the highest possible level of sample recovery.

Features of Protein Precipitation Plates:
• Prepare small molecule samples for HPLC or LC-MS in 10–30 minutes
• Compatible with most organic solvents
• No acetonitrile leakage for up to four hours
• Leach-free graded hydrophobic frit prevents blockage
• Filtrates are easily collected by vacuum, positive pressure or centrifugation
• Assay serum samples of 15 to 400 μL per well (2 mL well volume)

Specifications

• For Use With (Equipment): Mass Spectrometer, Centrifuge
• Product Line: Pierce™
• Starting Material: Protease-digested Protein
• Detection Method: Mass Spectrometry
• Workflow Step: Sample Clean Up

• Product Type: Protein Precipitation Plate
• Content And Storage: Upon receipt store plates at room temperature. Product shipped at ambient temperature.
• Final Product Type: Peptides
• Format: Plate