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Phleomycin, Fisher BioReagents

Catalog Number BP2962100
Click to view available options
Quantity:
100 mg
Packaging:
Plastic Bottle
11006-33-0
C51H75N17O21S2
1326.379
QRBLKGHRWFGINE-UGWAGOLRSA-N
72511
2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2S,3R,4R,5S)-4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)-
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)(C)OC4C(C(C(C(O4)CO)O)(C(=O)N)O)O)C(=O)NC(C)C(C(C)C(=O)NC(C(=O)C)C(=O)NCCC5=NC(CS5)C6=NC(=CS6)C(=O)N)O
11006-33-0
C51H75N17O21S2
1326.379
QRBLKGHRWFGINE-UGWAGOLRSA-N
72511
2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2S,3R,4R,5S)-4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)-
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)(C)OC4C(C(C(C(O4)CO)O)(C(=O)N)O)O)C(=O)NC(C)C(C(C)C(=O)NC(C(=O)C)C(=O)NCCC5=NC(CS5)C6=NC(=CS6)C(=O)N)O

Description

Disrupts the integrity of DNA, and blocks S-phase entry in the cell cycle

  • An antibiotic often used as selection agent to determine transformation efficiency of algae, fungi, and mammalian cells
  • Serves as a selection agent for transformed cells carrying the antibiotic-resistance gene Sh ble
  • Causes DNA fragmentation by introducting double-strand breaks in DNA and prevents cells from entering S-phase during the cell cycle
TRUSTED_SUSTAINABILITY
Type Phleomycin
Physical Form Liquid
Absorbance 0.75 to 1.05 AU at 244nm
Source Streptomyces verticillus
Odor None
Packaging Plastic Bottle
Formula Weight 1526.5
Sterile Filtered Pass Test
Quantity 100 mg
Chemical Name or Material Phleomycin

Safety and Handling

Hazard Statement WARNING!
Precautionary Statement Emergency Overview
May cause an allergic skin reaction. May cause skin, eye, and respiratory tract irritation. Limited evidence of a carcinogenic effect. Use personal protective equipment. Use only under a chemical fume hood. Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Obtain medical attention. Move to fresh air. If breathing is difficult, give oxygen. Get medical attention immediately if symptoms occur. Get medical attention immediately if symptoms occur. Do not induce vomiting.

NFPA

Health:2
Flammability:0
Instability:0
SDS
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