Nifedipine, 98%, Thermo Scientific Chemicals

Description

L-type calcium channel blocker; induces apoptosis in human glioblastoma cells

L-type calcium channel blocker; induces apoptosis in human glioblastoma cells.Nifedipine is a dihydropyridine calcium channel blocker used as L-type calcium channel blocker, antianginal and an antihypertensive . It induces apoptosis in human glioblastoma cells. It is used as a coronary vasodilator in the treatment of cardiac and circulatory disorders. Further, it is used in high-altitude medicine to treat high altitude pulmonary edema, hypertension and chronic stable angina. In addition, it is frequently used as a tocolytic agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
L-type calcium channel blocker; induces apoptosis in human glioblastoma cells.Nifedipine is a dihydropyridine calcium channel blocker used as L-type calcium channel blocker, antianginal and an antihypertensive . It induces apoptosis in human glioblastoma cells. It is used as a coronary vasodilator in the treatment of cardiac and circulatory disorders. Further, it is used in high-altitude medicine to treat high altitude pulmonary edema, hypertension and chronic stable angina. In addition, it is frequently used as a tocolytic agent.

Solubility
Soluble in acetone, methylene chloride, chloroform, ethyl acetate, dimethyl sulfoxide and methanol. Sparingly soluble in ethanol. Insoluble in water.

Notes
Light sensitive. Store in a cool place. Incompatible with strong acids, strong oxidizing agents, caustics, aliphatic amines, amides, diethylamine, potassium hydride and potassium hydroxide.

Specifications

Chemical Identifiers

• CAS: 21829-25-4
• Molecular Formula: C17H18N2O6
• Molecular Weight (g/mol): 346.34
• MDL Number: MFCD00057326
• InChI Key: HYIMSNHJOBLJNT-UHFFFAOYSA-N
• Synonym: nifedipine, procardia, adalat, procardia xl, adalat cc, cordipin, corinfar, fenihidine, citilat, oxcord
• PubChem CID: 4485
• ChEBI: CHEBI:7565
• IUPAC Name: 3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• SMILES: COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1[N+]([O-])=O)C(=O)OC

• Melting Point: 171°C to 175°C
• Color: White to Yellow
• Quantity: 5 g
• Merck Index: 14,6528
• Solubility Information: Soluble in acetone,methylene chloride,chloroform,ethyl acetate,dimethyl sulfoxide and methanol. Sparingly soluble in ethanol. Insoluble in water.
• Formula Weight: 346.33
• Percent Purity: 98%
• Physical Form: Powder
• Chemical Name or Material: Nifedipine

Safety and Handling

Hazard Category	H302
Hazard Statement	GHS H Statement H302 Harmful if swallowed.
Precautionary Statement	P264b-P270-P301+P312-P330-P501c
EINECSNumber	244-598-3
RTECSNumber	US7975000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only