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Necrostatin-1, Thermo Scientific Chemicals

Catalog Number AAJ65341FPL
Click to view available options
Quantity:
20 mg
4311-88-0
C13H13N3OS
259.327
MFCD00056916
TXUWMXQFNYDOEZ-UHFFFAOYSA-N
necrostatin-1, mth-dl-tryptophan, nec-1, necrostatin 1, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo-4-imidazolidinone, mth-trp, methyl-thiohydantoin-tryptophan, necroptotic inhibitor, nec-1, 5-1h-indol-3-ylmethyl-3-methyl-2-sulfanylideneimidazolidin-4-one, 4-imidazolidinone, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo
2828334
5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
4311-88-0
C13H13N3OS
259.327
MFCD00056916
TXUWMXQFNYDOEZ-UHFFFAOYSA-N
necrostatin-1, mth-dl-tryptophan, nec-1, necrostatin 1, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo-4-imidazolidinone, mth-trp, methyl-thiohydantoin-tryptophan, necroptotic inhibitor, nec-1, 5-1h-indol-3-ylmethyl-3-methyl-2-sulfanylideneimidazolidin-4-one, 4-imidazolidinone, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo
2828334
5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32

Description

 

Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any pe
TRUSTED_SUSTAINABILITY
Color Yellow
Quantity 20 mg
Sensitivity Light sensitive
Solubility Information Soluble in DMSO (10-25mg/ml),100% ethanol (6mg/ml),and methanol (5mg/ml).
Formula Weight 259.33
Physical Form Powder
Chemical Name or Material Necrostatin-1

Safety and Handling

TSCA No
storageNote1 2° to 8°C
Recommended Storage Keep cold
SDS

RUO – Research Use Only

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