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LE 135, Tocris Bioscience™

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Selective RARβ antagonist

Retinoic acid antagonist; displays moderate selectivity for RARβ over RARα (Ki values are 0.22 and 1.4 μM respectively). Highly selective over RARγ and RXRα. Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC50 = 150 nM).
CAS 155877-83-1
Molecular Formula C29H30N2O2
Quantity 50 mg
Synonym chembl37708, 4-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-5h-benzo e naphtho 2,3-b 1,4 diazepin-13-yl benzoic acid, d0x5wp, 4-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5h-5,12-diaza-benzo 4,5 cyclohepta 1,2-b naphthalen-13-yl-benzoic acid, 4-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5h-benzo e naphtho 2,3-b 1,4 diazepin-13-yl benzoic acid, 4-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho 2,3-b 1, 4 benzodiazepin-13-yl benzoic acid, 4-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho 2,3-b 1,4 benzodiazepin-13-yl benzoic acid
IUPAC Name 4-(5,7,7,10,10-pentamethyl-8,9-dihydronaphtho[2,3-b][1,4]benzodiazepin-13-yl)benzoic acid
Molecular Weight (g/mol) 438.571
PubChem CID 10410894
Formula Weight 438.56
Percent Purity >97%
Chemical Name or Material LE 135
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Recommended Storage : Store at +4°C