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  8. L-748,337, Tocris Bioscience™

L-748,337, Tocris Bioscience™

Catalog Number 276050
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
244192-94-7
C26H31N3O5S
497.61
AWIONHVPTYTSHZ-DEOSSOPVSA-N
n-3-2s-2-hydroxy-3-2-4-phenylsulfonyl amino phenyl ethyl amino propoxy phenyl methyl-acetamide, d03vhk, n-3-2s-2-hydroxy-3-2-4-phenylsulfonylamino phenyl ethylamino propoxy phenyl methyl acetamide
10028830
N-[[3-[(2S)-3-[2-[4-(benzenesulfonamido)phenyl]ethylamino]-2-hydroxypropoxy]phenyl]methyl]acetamide
CC(=O)NCC1=CC(=CC=C1)OCC(CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=CC=C3)O
This item is not returnable. View return policy
244192-94-7
C26H31N3O5S
497.61
AWIONHVPTYTSHZ-DEOSSOPVSA-N
n-3-2s-2-hydroxy-3-2-4-phenylsulfonyl amino phenyl ethyl amino propoxy phenyl methyl-acetamide, d03vhk, n-3-2s-2-hydroxy-3-2-4-phenylsulfonylamino phenyl ethylamino propoxy phenyl methyl acetamide
10028830
N-[[3-[(2S)-3-[2-[4-(benzenesulfonamido)phenyl]ethylamino]-2-hydroxypropoxy]phenyl]methyl]acetamide
CC(=O)NCC1=CC(=CC=C1)OCC(CNCCC2=CC=C(C=C2)NS(=O)(=O)C3=CC=CC=C3)O

Description

Selective β3 antagonist

Competitive β3-adrenoceptor antagonist that displays selectivity over β1 and β2 receptors (Ki values are 4.0, 204 and 390 nM for β3-, β2- and β1-adrenoceptors respectively). Inhibits cAMP accumulation in response to isoproterenol (IC50 = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line.
Quantity 50 mg
Formula Weight 497.61
Percent Purity >98%
Chemical Name or Material L-748, 337

Safety and Handling

Recommended Storage Store at +4°C
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