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L-161,982, Tocris Bioscience™

Catalog Number 251410
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Quantity:
10 mg
This item is not returnable. View return policy
147776-06-5
C32H29F3N4O4S2
654.723
MMDNKTXNUZFVKD-UHFFFAOYSA-N
chembl97688, 4-3-butyl-5-oxo-1-2-trifluoromethyl-phenyl-1,5-dihydro-1,2,4 triazol-4-ylmethyl-biphenyl-2-sulfonic acid 3-methyl-thiophene-2-carbonyl-amide; compound with dichloro-methane, n-4'-3-butyl-1,5-dihydro-5-oxo-1-2-trifluoromethyl phenyl-4h-1,2,4-triazol-4-yl methyl 1,1'-biphenyl-2-yl sulfonyl-3-methyl-2-thiophenecarboxamide
9961192
N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide
CCCCC1=NN(C(=O)N1CC2=CC=C(C=C2)C3=CC=CC=C3S(=O)(=O)NC(=O)C4=C(C=CS4)C)C5=CC=CC=C5C(F)(F)F
This item is not returnable. View return policy
147776-06-5
C32H29F3N4O4S2
654.723
MMDNKTXNUZFVKD-UHFFFAOYSA-N
chembl97688, 4-3-butyl-5-oxo-1-2-trifluoromethyl-phenyl-1,5-dihydro-1,2,4 triazol-4-ylmethyl-biphenyl-2-sulfonic acid 3-methyl-thiophene-2-carbonyl-amide; compound with dichloro-methane, n-4'-3-butyl-1,5-dihydro-5-oxo-1-2-trifluoromethyl phenyl-4h-1,2,4-triazol-4-yl methyl 1,1'-biphenyl-2-yl sulfonyl-3-methyl-2-thiophenecarboxamide
9961192
N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide
CCCCC1=NN(C(=O)N1CC2=CC=C(C=C2)C3=CC=CC=C3S(=O)(=O)NC(=O)C4=C(C=CS4)C)C5=CC=CC=C5C(F)(F)F

Description

Selective EP4 receptor antagonist

L-161,982 is an EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively). Suppresses PGE2-induced bone formation in rats and prevents the nociceptive response induced by Misoprostol (Cat. No. 2297) in formalin-injected mice.
Quantity 10 mg
Formula Weight 654.72
Percent Purity >99%
Chemical Name or Material L-161, 982

Safety and Handling

Recommended Storage Desiccate at +4°C
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