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  7. Thermo Scientific Chemicals Ketoconazole, 98%

Thermo Scientific Chemicals Ketoconazole, 98%

Catalog Number AC455470010
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Quantity:
1 g
5 g
25 g
65277-42-1
C26H28Cl2N4O4
531.44
XMAYWYJOQHXEEK-SIULDFEJSA-N
ketoconazole
76973198
2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
65277-42-1
C26H28Cl2N4O4
531.44
XMAYWYJOQHXEEK-SIULDFEJSA-N
ketoconazole
76973198
2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

Description

Ketoconazole, CAS # 65277-42-1, is a synthetic, broad-spectrum antifungal agent with the ability to inhibit a variety of fungal infections.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
• Ketoconazole is an imidazole antifungal agent
• It functions by inhibiting synthesis of ergosterol, which is the fungal equivalent of cholesterol
Applications
• Ketoconazole shows fungicide activity against a variety of yeast infections
• It is an inhibitor of CYP3A4, which is necessary for the conversion of lanosterol to ergosterol
• It increases fungal cellular permeability
• It also inhibits endogenous respiration by disrupting membrane phospholipids
• Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone
TRUSTED_SUSTAINABILITY
Melting Point 148.0°C to 150.0°C
Loss on Drying 0.5% max. (80°C, 4 h) (vacuum)
Infrared Spectrum Authentic
Assay Percent Range 97.5% min. (HPLC)
Packaging Glass Bottle
Quantity 1 g
Solubility Information Solubility in water: almost insoluble. Other solubilities: soluble in methanol,less soluble in ethanol,slightly soluble in dichloromethane or chloroform
Formula Weight 531.44
Percent Purity 98%
Chemical Name or Material Ketoconazole

Safety and Handling

Hazard Category GHS Signal Word: Danger
Hazard Statement GHS H Statement
May damage fertility.
Toxic if swallowed.
May cause damage to organs through prolonged or repeated exposure if swallowed.
Very toxic to aquatic life with long lasting effects.
Precautionary Statement GHS P Statement
Obtain special instructions before use.
Use personal protective equipment as required.
IF exposed or concerned: Get medical advice/attention.
Do not get in eyes,on skin,or on clothing.
Do not eat,drink or smoke
EINECSNumber 265-667-4
SDS

RUO – Research Use Only

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