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  7. JZL 184, Tocris Bioscience™

JZL 184, Tocris Bioscience™

Catalog Number 383650
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
1101854-58-3
C27H24N2O9
520.494
SEGYOKHGGFKMCX-UHFFFAOYSA-N
unii-7mz1i2j68a, 4-nitrophenyl 4-bis 2h-1,3-benzodioxol-5-yl hydroxy methyl piperidine-1-carboxylate, 4-nitrophenyl 4-dibenzo d 1,3 dioxol-5-yl hydroxy methyl piperidine-1-carboxylate, 1-piperidinecarboxylic acid, 4-bis 1,3-benzodioxol-5-yl hydroxymethyl-, 4-nitrophenyl ester, d0g0mz, 4-bis 1,3-benzodioxol-5-yl hydroxymethyl-1-piperidinecarboxylic acid 4-nitrophenyl ester, 4-nitrophenyl 4-bis benzo d 1,3 dioxol-5-yl hydroxy methyl piperidine-1-carboxylate, 4-nitrophenyl 4-dibenzo d 1,3 dioxol-5-yl-hydroxy methyl piperidine-1-carboxylate, 4-nitrophenyl 4-bis 1,3-benzodioxol-5-yl hydroxy methyl-1-piperidinecarboxylate
25021165
(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
This item is not returnable. View return policy
1101854-58-3
C27H24N2O9
520.494
SEGYOKHGGFKMCX-UHFFFAOYSA-N
unii-7mz1i2j68a, 4-nitrophenyl 4-bis 2h-1,3-benzodioxol-5-yl hydroxy methyl piperidine-1-carboxylate, 4-nitrophenyl 4-dibenzo d 1,3 dioxol-5-yl hydroxy methyl piperidine-1-carboxylate, 1-piperidinecarboxylic acid, 4-bis 1,3-benzodioxol-5-yl hydroxymethyl-, 4-nitrophenyl ester, d0g0mz, 4-bis 1,3-benzodioxol-5-yl hydroxymethyl-1-piperidinecarboxylic acid 4-nitrophenyl ester, 4-nitrophenyl 4-bis benzo d 1,3 dioxol-5-yl hydroxy methyl piperidine-1-carboxylate, 4-nitrophenyl 4-dibenzo d 1,3 dioxol-5-yl-hydroxy methyl piperidine-1-carboxylate, 4-nitrophenyl 4-bis 1,3-benzodioxol-5-yl hydroxy methyl-1-piperidinecarboxylate
25021165
(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]

Description

Potent MAGL inhibitor

Potent and selective MAGL inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM). Potentiates depolarization-induced suppression of excitability in cerebellar Purkinje neurons. Exhibits >300-fold selectivity for MAGL over FAAH in vitro. Attenuates nociception in neuropathic and inflammatory pain models. Also reduces free fatty acid levels in primary tumors.
Quantity 50 mg
Formula Weight 520.49
Percent Purity >98%
Chemical Name or Material JZL 184

Safety and Handling

Recommended Storage Store at -20°C
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