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IWP 2, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
IWP 2 is a potent inhibitor of Wnt processing and secretion (IC50 = 27nM). IWP 2 inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. IWP 2 suppresses self-renewal in R1 embryonic stem cells and promotes cardiomyocyte differentiation from hPSCs.
Specifications
Quantity | 50 mg |
Formula Weight | 466.6 |
Percent Purity | >98% |
Chemical Name or Material | IWP 2 |
Safety and Handling
Recommended Storage | Store at +4°C |
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