Thermo Scientific™ ImmunoCAP™ Weed Pollen Allergens

Measure specifc IgE antibodies using ImmunoCAP™ allergens, an essential tool to aid in the diagnosis of allergic conditions.

Catalog Number	Mfr. No.	Common Name	Scientific Name	Code	Quantity
14-410-401P	Thermo Scientific™ 14410401	Wall pellitory	Parietaria judaica	w21	16 Tests
14-410-301P	Thermo Scientific™ 14410301	Mugwort	Artemisia vulgaris	w6	16 Tests
14-415-501P	Thermo Scientific™ 14415501	Dandelion	Taraxacum vulgare	w8	16 Tests
14-415-301P	Thermo Scientific™ 14415301	Giant ragweed	Ambrosia trifida	w3	16 Tests
14-415-401P	Thermo Scientific™ 14415401	Marguerite, Ox-eye daisy	Chrysanthemum leucanthemum	w7	16 Tests
14-415-201P	Thermo Scientific™ 14415201	Western ragweed	Ambrosia psilostachya	w2	16 Tests
14-415-601P	Thermo Scientific™ 14415601	Plantain (English), Ribwort	Plantago lanceolata	w9	16 Tests
14-415-701P	Thermo Scientific™ 14415701	Goosefoot, Lamb’s quarters	Chenopodium album	w10	16 Tests
14-418-601P	Thermo Scientific™ 14418601	Wall pellitory	Parietaria officinalis	w19	16 Tests
14-424-701P	Thermo Scientific™ 14424701	False ragweed	Franseria acanthicarpa	w4	16 Tests
14-424-801P	Thermo Scientific™ 14424801	Wormwood	Artemisia absinthium	w5	16 Tests
14-425-201P	Thermo Scientific™ 14425201	Common pigweed	Amaranthus retroflexus	w14	16 Tests
14-424-901P	Thermo Scientific™ 14424901	Saltwort (prickly), Russian thistle	Salsola kali (pestifer)	w11	16 Tests
14-425-001P	Thermo Scientific™ 14425001	Goldenrod	Solidago virgaurea	w12	16 Tests
14-425-301P	Thermo Scientific™ 14425301	Scale, Lenscale	Atriplex lentiformis	w15	16 Tests
14-425-101P	Thermo Scientific™ 14425101	Cocklebur	Xanthium commune	w13	16 Tests
14-425-501P	Thermo Scientific™ 14425501	Firebush (Kochia)	Kochia scoparia	w17	16 Tests
14-425-401P	Thermo Scientific™ 14425401	Rough marshelder	Iva ciliata	w16	16 Tests
14-425-601P	Thermo Scientific™ 14425601	Sheep sorrel	Rumex acetosella	w18	16 Tests
14-425-701P	Thermo Scientific™ 14425701	Nettle	Urtica dioica	w20	16 Tests
14-495-010P	Thermo Scientific™ 14495010	Yellow dock	Rumex crispus	Rw23	10 Tests
14-495-110P	Thermo Scientific™ 14495110	Alfalfa	Medicago sativa	Rw45	10 Tests
14-495-310P	Thermo Scientific™ 14495310	Careless weed	Amaranthus palmeri	Rw82	10 Tests
14-495-210P	Thermo Scientific™ 14495210	Dog fennel	Eupatorium capillifolium	Rw46	10 Tests
14-502-410P	Thermo Scientific™ 14502410	Rape	Brassica napus	Rw203	10 Tests
14-502-210P	Thermo Scientific™ 14502210	Lupin	Lupinus spp.	Rw207	10 Tests
14-502-510P	Thermo Scientific™ 14502510	Sunflower	Helianthus annuus	Rw204	10 Tests
14-416-201P	Thermo Scientific™ 14416201	Common ragweed	Ambrosia elatior (A. artemisiifolia)	w1	16 Tests

Description

Quantify specific IgE antibodies with ImmunoCAP™ Weed Pollen Allergens, essential tools to aid in the diagnosis of allergic conditions. IgE antibodies appear in human serum and plasma as a result of sensitization to a specific allergen. Measurement of circulating IgE antibodies provides an objective assessment of sensitization to an allergen. In general, low IgE antibody levels indicate a low probability of allergic disease, whereas high antibody levels to an allergen show a higher correlation with an allergic disease.

ImmunoCAP Specific IgE offers the laboratory:

• Truly quantitative measuring range from 0.1 to 100 kUA/L
• Intra-assay CV (%) comparable to routine clinical chemistry immunoassays
• Excellent consistency over time, and between countries, systems, labs and persons

Expected test values
ImmunoCAP Specific IgE detects IgE antibodies in the range 0.1 to 100 kUA /l, where A represents allergen-specific antibodies. The result is reported quantitatively. In clinical practice, 0.35 kUA /l has commonly been used as a cut-off. A large number of studies have been performed to evaluate the clinical performance of ImmunoCAP Specific IgE tests in allergy diagnosis. Clinical performance is expressed as sensitivity, ranging from 84 to 95%, and specificity, ranging from 85 to 94%. Sensitivity and specificity were reported from multi-center studies including several hundred patients tested for a range of different allergens.

• Specimen collection and preparation
• Use serum and plasma (EDTA or heparin) samples from venous or capillary blood
• Collect blood samples using standard procedures
• Keep specimens at room temperature (RT) for shipping purposes only
• Store at 2–8°C up to one week, otherwise store at –20°C
• Avoid repeated freezing and thawing

Note: Blood samples for testing ImmunoCAP drugs and venom should be collected during or close to the event, preferably not later than 6 months after exposure. If the test result is negative and an IgE-mediated reaction is still strongly suspected, it is advisable to draw a new sample and repeat the test at 5 to 6 weeks.

The presence of specific IgE antibodies is useful to identify the allergens that elicit symptoms and signs of allergy in patients with respiratory allergic diseases including asthma, food allergy, and anaphylactic sensitivity.

Knowing IgE antibody levels provides guidance to clinicians to:

• Identify offending allergens
• Tailor advice to individual patients
• Indicate development of tolerance (food allergy, specific immunotherapy)
• Inform optimized individual medical treatment plans
• Refer to specialists appropriately
• Evaluate whether or not specific immunotherapy is an option

Specific IgE testing also aids in the identification of patients at risk of:

• The allergy march – a progression of skin symptoms to respiratory symptoms
• Severe symptoms including asthma exacerbations – a progression of mild symptoms to severe symptoms
• Progression of recurrent symptoms to persistent symptoms

As in all diagnostic testing, a definitive clinical diagnosis should be made by the clinician after evaluation of all clinical and laboratory findings.

Specifications

• Code Type: Weed