Thermo Scientific™ ImmunoCAP™ Spice Allergens

Measure specifc IgE antibodies using ImmunoCAP™ allergens, an essential tool to aid in the diagnosis of allergic conditions.

Catalog Number	Mfr. No.	Common Name	Scientific Name	Code	Quantity
14-429-701P	Thermo Scientific™ 14429701	Parsley	Petroselinum crispum	f86	10 Tests
14-432-901P	Thermo Scientific™ 14432901	Mustard	Brassica/Sinapis spp.	f89	10 Tests
14-481-601P	Thermo Scientific™ 14481601	Paprika, Sweet pepper	Capsicum annuum	f218	10 Tests
14-481-701P	Thermo Scientific™ 14481701	Black pepper	Piper nigrum	f280	10 Tests
14-504-410P	Thermo Scientific™ 14504410	Anise	Pimpinella anisum	Rf271	10 Tests
14-504-910P	Thermo Scientific™ 14504910	Bay leaf	Laurus nobilis	Rf278	10 Tests
14-504-810P	Thermo Scientific™ 14504810	Basil	Ocimum basilicum	Rf269	10 Tests
14-505-710P	Thermo Scientific™ 14505710	Caraway	Carum carvi	Rf265	10 Tests
14-506-210P	Thermo Scientific™ 14506210	Chilipepper	Capsicum frutescens	Rf279	10 Tests
14-506-310P	Thermo Scientific™ 14506310	Cinnamon	Cinnamomum spp.	Rf220	10 Tests
14-506-410P	Thermo Scientific™ 14506410	Clove	Syzygium aromaticum	Rf268	10 Tests
14-506-910P	Thermo Scientific™ 14506910	Dill	Anethum graveolens	Rf277	10 Tests
14-507-210P	Thermo Scientific™ 14507210	Ginger	Zingiber officinale	Rf270	10 Tests
14-507-510P	Thermo Scientific™ 14507510	Green pepper (unripe seed)	Piper nigrum	Rf263	10 Tests
14-508-310P	Thermo Scientific™ 14508310	Mace	Myristica fragrans	Rf266	10 Tests
14-508-410P	Thermo Scientific™ 14508410	Marjoram	Origanum majorana	Rf274	10 Tests
14-508-710P	Thermo Scientific™ 14508710	Nutmeg	Myristica fragrans	Rf282	10 Tests
14-508-810P	Thermo Scientific™ 14508810	Oregano	Origanum vulgare	Rf283	10 Tests
14-510-310P	Thermo Scientific™ 14510310	Tarragon	Artemisia dracunculus	Rf272	10 Tests
14-510-610P	Thermo Scientific™ 14510610	Vanilla	Vanilla planifolia	Rf234	10 Tests
14-510-510P	Thermo Scientific™ 14510510	Thyme	Thymus vulgaris	Rf273	10 Tests
14-521-410P	Thermo Scientific™ 14521410	Coriander	Coriandrum sativum	Rf317	10 Tests
14-524-910P	Thermo Scientific™ 14524910	Mint	Mentha piperita	Rf332	10 Tests
14-505-810P	Thermo Scientific™ 14505810	Cardamon	Elettaria cardamomum	Rf267	10 Tests
14-506-710P	Thermo Scientific™ 14506710	Curry (Santa Maria)		Rf281	10 Tests

Description

Quantify specific IgE antibodies with the ImmunoCAP™ Spice Allergens, essential tools to aid in the diagnosis of allergic conditions. IgE antibodies appear in human serum and plasma as a result of sensitization to a specific allergen. Measurement of circulating IgE antibodies provides an objective assessment of sensitization to an allergen. In general, low IgE antibody levels indicate a low probability of allergic disease, whereas high antibody levels to an allergen show a higher correlation with an allergic disease.

ImmunoCAP Specific IgE offers the laboratory:

• Truly quantitative measuring range from 0.1 to 100 kUA/L
• Intra-assay CV (%) comparable to routine clinical chemistry immunoassays
• Excellent consistency over time, and between countries, systems, labs and persons

Expected test values
ImmunoCAP Specific IgE detects IgE antibodies in the range 0.1 to 100 kUA /l, where A represents allergen-specific antibodies. The result is reported quantitatively. In clinical practice, 0.35 kUA /l has commonly been used as a cut-off. A large number of studies have been performed to evaluate the clinical performance of ImmunoCAP Specific IgE tests in allergy diagnosis. Clinical performance is expressed as sensitivity, ranging from 84 to 95%, and specificity, ranging from 85 to 94%. Sensitivity and specificity were reported from multi-center studies including several hundred patients tested for a range of different allergens.

• Specimen collection and preparation
• Use serum and plasma (EDTA or heparin) samples from venous or capillary blood
• Collect blood samples using standard procedures
• Keep specimens at room temperature (RT) for shipping purposes only
• Store at 2–8°C up to one week, otherwise store at –20°C
• Avoid repeated freezing and thawing

Note: Blood samples for testing ImmunoCAP drugs and venom should be collected during or close to the event, preferably not later than 6 months after exposure. If the test result is negative and an IgE-mediated reaction is still strongly suspected, it is advisable to draw a new sample and repeat the test at 5 to 6 weeks.

The presence of specific IgE antibodies is useful to identify the allergens that elicit symptoms and signs of allergy in patients with respiratory allergic diseases including asthma, food allergy, and anaphylactic sensitivity.

Knowing IgE antibody levels provides guidance to clinicians to:

• Identify offending allergens
• Tailor advice to individual patients
• Indicate development of tolerance (food allergy, specific immunotherapy)
• Inform optimized individual medical treatment plans
• Refer to specialists appropriately
• Evaluate whether or not specific immunotherapy is an option

Specific IgE testing also aids in the identification of patients at risk of:

• The allergy march – a progression of skin symptoms to respiratory symptoms
• Severe symptoms including asthma exacerbations – a progression of mild symptoms to severe symptoms
• Progression of recurrent symptoms to persistent symptoms

As in all diagnostic testing, a definitive clinical diagnosis should be made by the clinician after evaluation of all clinical and laboratory findings.

Specifications

• Code Type: Spice
• Quantity: 10 Tests