Thermo Scientific™ ImmunoCAP™ Seed, Legume and Nut Allergens

Measure specifc IgE antibodies using ImmunoCAP™ allergens, an essential tool to aid in the diagnosis of allergic conditions.

Catalog Number	Mfr. No.	Common Name	Scientific Name	Code	Quantity
14-411-501P	Thermo Scientific™ 14411501	Soybean	Glycine max	f14	16 Tests
14-411-301P	Thermo Scientific™ 14411301	Wheat	Triticum aestivum	f4	16 Tests
14-412-601P	Thermo Scientific™ 14412601	Peanut	Arachis hypogaea	f13	16 Tests
14-412-501P	Thermo Scientific™ 14412501	Buckwheat	Fagopyrum esculentum	f11	16 Tests
14-412-401P	Thermo Scientific™ 14412401	Maize, Corn	Zea mays	f8	16 Tests
14-412-301P	Thermo Scientific™ 14412301	Rye	Secale cereale	f5	16 Tests
14-417-201P	Thermo Scientific™ 14417201	Barley	Hordeum vulgare	f6	16 Tests
14-417-301P	Thermo Scientific™ 14417301	Oat	Avena sativa	f7	16 Tests
14-417-601P	Thermo Scientific™ 14417601	Pea	Pisum sativum	f12	16 Tests
14-417-401P	Thermo Scientific™ 14417401	Rice	Oryza sativa	f9	16 Tests
14-417-501P	Thermo Scientific™ 14417501	Sesame seed	Sesamum indicum	f10	16 Tests
14-417-701P	Thermo Scientific™ 14417701	White bean	Phaseolus vulgaris	f15	16 Tests
14-417-801P	Thermo Scientific™ 14417801	Brazil nut	Bertholletia excelsa	f18	16 Tests
14-417-901P	Thermo Scientific™ 14417901	Almond	Amygdalus communis	f20	16 Tests
14-421-201P	Thermo Scientific™ 14421201	Coconut	Cocos nucifera	f36	16 Tests
14-429-101P	Thermo Scientific™ 14429101	Gluten		f79	10 Tests
14-445-901P	Thermo Scientific™ 14445901	Common millet	Panicum milliaceum	f55	16 Tests
14-446-001P	Thermo Scientific™ 14446001	Foxtail millet	Setaria italica	f56	16 Tests
14-452-101P	Thermo Scientific™ 14452101	Walnut	Juglans spp.	f256	16 Tests
14-452-801P	Thermo Scientific™ 14452801	Hazel nut	Corylus avellana	f17	16 Tests
14-480-701P	Thermo Scientific™ 14480701	Pecan nut	Carya illinoensis	f201	10 Tests
14-481-501P	Thermo Scientific™ 14481501	Lentil	Lens esculenta	f235	10 Tests
14-483-601P	Thermo Scientific™ 14483601	Pistachio	Pistacia vera	f203	10 Tests
14-483-501P	Thermo Scientific™ 14483501	Cashew nut	Anacardium occidentale	f202	10 Tests
14-484-301P	Thermo Scientific™ 14484301	Sweet chestnut	Castanea sativa	f299	10 Tests
14-492-910P	Thermo Scientific™ 14492910	Lima bean	Phaseolus lunatus	Rf182	10 Tests
14-509-310P	Thermo Scientific™ 14509310	Pine nut, pignoles	Pinus edulis	Rf253	10 Tests
14-509-710P	Thermo Scientific™ 14509710	Poppy seed	Papaver somniferum	Rf224	10 Tests
14-510-010P	Thermo Scientific™ 14510010	Red kidney bean	Phaseolus vulgaris	Rf287	10 Tests
14-510-210P	Thermo Scientific™ 14510210	Sugar-beet seed	Beta vulgaris	Rf227	10 Tests
14-509-810P	Thermo Scientific™ 14509810	Pumpkin seed	Cucurbita pepo	Rf226	10 Tests
14-518-710P	Thermo Scientific™ 14518710	Fenugreek	Trigonella foenum-graecum	Rf305	10 Tests
14-519-601P	Thermo Scientific™ 14519601	Chick pea	Cicer arietinus	f309	10 Tests
14-521-110P	Thermo Scientific™ 14521110	Green bean	Phaseolus vulgaris	Rf315	10 Tests
14-521-310P	Thermo Scientific™ 14521310	Rape seed	Brassica napus	Rf316	10 Tests
14-525-010P	Thermo Scientific™ 14525010	Linseed	Linum usitatissimum	Rf333	10 Tests
14-525-410P	Thermo Scientific™ 14525410	Lupin seed	Lupinus albus	Rf335	10 Tests
14-528-210P	Thermo Scientific™ 14528210	Macadamia nut	Macadamia spp.	Rf345	10 Tests
14-528-410P	Thermo Scientific™ 14528410	Quinoa	Chenopodium quinoa	Rf347	10 Tests

Description

Quantify specific IgE antibodies with ImmunoCAP™ Seed, Legume and Nut Allergens, essential tools to aid in the diagnosis of allergic conditions. IgE antibodies appear in human serum and plasma as a result of sensitization to a specific allergen. Measurement of circulating IgE antibodies provides an objective assessment of sensitization to an allergen. In general, low IgE antibody levels indicate a low probability of allergic disease, whereas high antibody levels to an allergen show a higher correlation with an allergic disease.

ImmunoCAP Specific IgE offers the laboratory:

• Truly quantitative measuring range from 0.1 to 100 kUA/L
• Intra-assay CV (%) comparable to routine clinical chemistry immunoassays
• Excellent consistency over time, and between countries, systems, labs and persons

Expected test values
ImmunoCAP Specific IgE detects IgE antibodies in the range 0.1 to 100 kUA /l, where A represents allergen-specific antibodies. The result is reported quantitatively. In clinical practice, 0.35 kUA /l has commonly been used as a cut-off. A large number of studies have been performed to evaluate the clinical performance of ImmunoCAP Specific IgE tests in allergy diagnosis. Clinical performance is expressed as sensitivity, ranging from 84 to 95%, and specificity, ranging from 85 to 94%. Sensitivity and specificity were reported from multi-center studies including several hundred patients tested for a range of different allergens.

• Specimen collection and preparation
• Use serum and plasma (EDTA or heparin) samples from venous or capillary blood
• Collect blood samples using standard procedures
• Keep specimens at room temperature (RT) for shipping purposes only
• Store at 2–8°C up to one week, otherwise store at –20°C
• Avoid repeated freezing and thawing

Note: Blood samples for testing ImmunoCAP drugs and venom should be collected during or close to the event, preferably not later than 6 months after exposure. If the test result is negative and an IgE-mediated reaction is still strongly suspected, it is advisable to draw a new sample and repeat the test at 5 to 6 weeks.

The presence of specific IgE antibodies is useful to identify the allergens that elicit symptoms and signs of allergy in patients with respiratory allergic diseases including asthma, food allergy, and anaphylactic sensitivity.

Knowing IgE antibody levels provides guidance to clinicians to:

• Identify offending allergens
• Tailor advice to individual patients
• Indicate development of tolerance (food allergy, specific immunotherapy)
• Inform optimized individual medical treatment plans
• Refer to specialists appropriately
• Evaluate whether or not specific immunotherapy is an option

Specific IgE testing also aids in the identification of patients at risk of:

• The allergy march – a progression of skin symptoms to respiratory symptoms
• Severe symptoms including asthma exacerbations – a progression of mild symptoms to severe symptoms
• Progression of recurrent symptoms to persistent symptoms

As in all diagnostic testing, a definitive clinical diagnosis should be made by the clinician after evaluation of all clinical and laboratory findings.

Specifications

• Code Type: Seed, Legume, and Nut