Thermo Scientific™ ImmunoCAP™ Fish, Shellfish and Mollusk Allergens

Measure specifc IgE antibodies using ImmunoCAP™ allergens, an essential tool to aid in the diagnosis of allergic conditions.

Catalog Number	Mfr. No.	Common Name	Scientific Name	Code	Quantity
14-415-901P	Thermo Scientific™ 14415901	Fish (cod)	Gadus morhua	f3	16 Tests
14-418-001P	Thermo Scientific™ 14418001	Crab	Cancer pagurus	f23	16 Tests
14-418-101P	Thermo Scientific™ 14418101	Shrimp	Pandalus borealis, Penaeus monodon, Metapenaeopsis barbata, Metapenaeus joyneri	f24	16 Tests
14-421-301P	Thermo Scientific™ 14421301	Blue mussel	Mytilus edulis	f37	16 Tests
14-421-401P	Thermo Scientific™ 14421401	Tuna	Thunnus albacares	f40	16 Tests
14-421-501P	Thermo Scientific™ 14421501	Salmon	Salmo salar	f41	16 Tests
14-429-201P	Thermo Scientific™ 14429201	Lobster	Homarus gammarus	f80	10 Tests
14-443-401P	Thermo Scientific™ 14443401	Plaice	Pleuronectes platessa	f254	16 Tests
14-445-401P	Thermo Scientific™ 14445401	Chub mackerel	Scomber japonicus	f50	16 Tests
14-446-201P	Thermo Scientific™ 14446201	Pacific squid	Todarodes pacificus	f58	16 Tests
14-446-301P	Thermo Scientific™ 14446301	Octopus	Octopus vulgaris	f59	16 Tests
14-446-501P	Thermo Scientific™ 14446501	Sardine, Japanese Pilchard	Sardinops melanosticta	f61	16 Tests
14-446-401P	Thermo Scientific™ 14446401	Jack mackerel, Scad	Trachurus japonicus	f60	16 Tests
14-481-901P	Thermo Scientific™ 14481901	Trout	Oncorhynchus mykiss (Salmo gairdnieri)	f204	10 Tests
14-482-001P	Thermo Scientific™ 14482001	Clam	Ruditapes spp.	f207	10 Tests
14-483-701P	Thermo Scientific™ 14483701	Herring	Clupea harengus	f205	10 Tests
14-484-201P	Thermo Scientific™ 14484201	Oyster	Ostrea edulis	f290	10 Tests
14-489-501P	Thermo Scientific™ 14489501	Scallop	Pecten spp.	f338	10 Tests
14-493-110P	Thermo Scientific™ 14493110	Red snapper	Lutjanus campechanus	Rf381	10 Tests
14-492-810P	Thermo Scientific™ 14492810	Gulf flounder	Paralichthys albigutta	Rf147	10 Tests
14-493-210P	Thermo Scientific™ 14493210	Whitefish (Inconnu)	Stenodus spp.	Rf384	10 Tests
14-493-010P	Thermo Scientific™ 14493010	Cat fish	Ictalurus punctatus	Rf369	10 Tests
14-493-710P	Thermo Scientific™ 14493710	Tilapia	Oreochromis spp.	Rf414	10 Tests
14-493-910P	Thermo Scientific™ 14493910	Haddock	Melanogrammus aeglefinus	Rf42	10 Tests
14-493-810P	Thermo Scientific™ 14493810	Walleye pike	Sander vitreus (Stizostedion vitreum)	Rf415	10 Tests
14-493-610P	Thermo Scientific™ 14493610	Pollock	Pollachius virens	Rf413	10 Tests
14-501-910P	Thermo Scientific™ 14501910	Mackerel	Scomber scombrus	Rf206	10 Tests
14-514-210P	Thermo Scientific™ 14514210	Squid	Loligo spp.	Rf258	10 Tests
14-515-910P	Thermo Scientific™ 14515910	Langust (spiny lobster)	Palinurus spp.	Rf304	10 Tests
14-515-810P	Thermo Scientific™ 14515810	Halibut	Hippoglossus hippoglossus	Rf303	10 Tests
14-519-410P	Thermo Scientific™ 14519410	Hake	Merluccius merluccius	Rf307	10 Tests
14-519-510P	Thermo Scientific™ 14519510	Sardine (Pilchard)	Sardina pilchardus	Rf308	10 Tests
14-520-410P	Thermo Scientific™ 14520410	Megrim	Lepidorhombus whiffiagonis	Rf311	10 Tests
14-520-510P	Thermo Scientific™ 14520510	Swordfish	Xiphias gladius	Rf312	10 Tests
14-521-010P	Thermo Scientific™ 14521010	Snail	Helix aspersa	Rf314	10 Tests
14-520-910P	Thermo Scientific™ 14520910	Anchovy	Engraulis encrasicolus	Rf313	10 Tests
14-521-910P	Thermo Scientific™ 14521910	Crayfish	Astacus astacus	Rf320	10 Tests
14-525-610P	Thermo Scientific™ 14525610	Sole	Solea solea	Rf337	10 Tests
14-528-310P	Thermo Scientific™ 14528310	Abalone	Haliotis spp.	Rf346	10 Tests

Description

Quantify specific IgE antibodies with ImmunoCAP™ Fish, Shellfish and Mollusk Allergens, essential tools to aid in the diagnosis of allergic conditions. IgE antibodies appear in human serum and plasma as a result of sensitization to a specific allergen. Measurement of circulating IgE antibodies provides an objective assessment of sensitization to an allergen. In general, low IgE antibody levels indicate a low probability of allergic disease, whereas high antibody levels to an allergen show a higher correlation with an allergic disease.

ImmunoCAP Specific IgE offers the laboratory:

• Truly quantitative measuring range from 0.1 to 100 kUA/L
• Intra-assay CV (%) comparable to routine clinical chemistry immunoassays
• Excellent consistency over time, and between countries, systems, labs and persons

Expected test values
ImmunoCAP Specific IgE detects IgE antibodies in the range 0.1 to 100 kUA /l, where A represents allergen-specific antibodies. The result is reported quantitatively. In clinical practice, 0.35 kUA /l has commonly been used as a cut-off. A large number of studies have been performed to evaluate the clinical performance of ImmunoCAP Specific IgE tests in allergy diagnosis. Clinical performance is expressed as sensitivity, ranging from 84 to 95%, and specificity, ranging from 85 to 94%. Sensitivity and specificity were reported from multi-center studies including several hundred patients tested for a range of different allergens.

• Specimen collection and preparation
• Use serum and plasma (EDTA or heparin) samples from venous or capillary blood
• Collect blood samples using standard procedures
• Keep specimens at room temperature (RT) for shipping purposes only
• Store at 2–8°C up to one week, otherwise store at –20°C
• Avoid repeated freezing and thawing

Note: Blood samples for testing ImmunoCAP drugs and venom should be collected during or close to the event, preferably not later than 6 months after exposure. If the test result is negative and an IgE-mediated reaction is still strongly suspected, it is advisable to draw a new sample and repeat the test at 5 to 6 weeks.

The presence of specific IgE antibodies is useful to identify the allergens that elicit symptoms and signs of allergy in patients with respiratory allergic diseases including asthma, food allergy, and anaphylactic sensitivity.

Knowing IgE antibody levels provides guidance to clinicians to:

• Identify offending allergens
• Tailor advice to individual patients
• Indicate development of tolerance (food allergy, specific immunotherapy)
• Inform optimized individual medical treatment plans
• Refer to specialists appropriately
• Evaluate whether or not specific immunotherapy is an option

Specific IgE testing also aids in the identification of patients at risk of:

• The allergy march – a progression of skin symptoms to respiratory symptoms
• Severe symptoms including asthma exacerbations – a progression of mild symptoms to severe symptoms
• Progression of recurrent symptoms to persistent symptoms

As in all diagnostic testing, a definitive clinical diagnosis should be made by the clinician after evaluation of all clinical and laboratory findings.

Specifications

• Code Type: Fish, Shellfish, and Mollusk