Thermo Scientific™ ImmunoCAP™ Epidermal and Animal Protein Allergens

Measure specific IgE antibodies using ImmunoCAP™ allergens, an essential tool to aid in the diagnosis of allergic conditions.

Catalog Number	Mfr. No.	Common Name	Code	Quantity	Regulatory Status
14-411-001P	Thermo Scientific™ 14411001	Dog dander	e5	16 Tests	FDA Cleared
14-410-901P	Thermo Scientific™ 14410901	Cat dander	e1	16 Tests	FDA Cleared
14-412-201P	Thermo Scientific™ 14412201	Horse dander	e3	16 Tests	FDA Cleared
14-416-601P	Thermo Scientific™ 14416601	Cow dander	e4	16 Tests	FDA Cleared
14-416-701P	Thermo Scientific™ 14416701	Guinea pig epithelium	e6	16 Tests	FDA Cleared
14-416-901P	Thermo Scientific™ 14416901	Goose feathers	e70	16 Tests	FDA Cleared
14-417-001P	Thermo Scientific™ 14417001	Chicken feathers	e85	10 Tests	FDA Cleared
14-417-101P	Thermo Scientific™ 14417101	Duck feathers	e86	10 Tests	FDA Cleared
14-430-401P	Thermo Scientific™ 14430401	Budgerigar feathers	e78	10 Tests	FDA Cleared
14-430-801P	Thermo Scientific™ 14430801	Rabbit epithelium	e82	10 Tests	FDA Cleared
14-430-301P	Thermo Scientific™ 14430301	Budgerigar droppings	e77	10 Tests	FDA Cleared
14-430-701P	Thermo Scientific™ 14430701	Sheep epithelium	e81	10 Tests	FDA Cleared
14-430-901P	Thermo Scientific™ 14430901	Swine epithelium	e83	10 Tests	FDA Cleared
14-430-601P	Thermo Scientific™ 14430601	Goat epithelium	e80	10 Tests	FDA Cleared
14-431-001P	Thermo Scientific™ 14431001	Hamster epithelium	e84	10 Tests	FDA Cleared
14-432-601P	Thermo Scientific™ 14432601	Rat epithelium, serum proteins and urine proteins	e87	10 Tests	FDA Cleared
14-432-701P	Thermo Scientific™ 14432701	Mouse epithelium, serum proteins and urine proteins	e88	10 Tests	FDA Cleared
14-435-601P	Thermo Scientific™ 14435601	Turkey feathers	e89	10 Tests	FDA Cleared
14-439-401P	Thermo Scientific™ 14439401	Mouse epithelium	e71	10 Tests	FDA Cleared
14-439-501P	Thermo Scientific™ 14439501	Mouse urine proteins	e72	10 Tests	FDA Cleared
14-439-701P	Thermo Scientific™ 14439701	Rat urine proteins	e74	10 Tests	FDA Cleared
14-439-601P	Thermo Scientific™ 14439601	Rat epithelium	e73	10 Tests	FDA Cleared
14-439-901P	Thermo Scientific™ 14439901	Mouse serum proteins	e76	10 Tests	FDA Cleared
14-439-801P	Thermo Scientific™ 14439801	Rat serum proteins	e75	10 Tests	FDA Cleared
14-482-401P	Thermo Scientific™ 14482401	Canary bird feathers	e201	10 Tests	FDA Cleared
14-501-310P	Thermo Scientific™ 14501310	Finch feathers	Re214	10 Tests	ASR
14-501-510P	Thermo Scientific™ 14501510	Gerbil epithelium	Re209	10 Tests	ASR
14-503-410P	Thermo Scientific™ 14503410	Rabbit, urine proteins	Re211	10 Tests	ASR
14-503-210P	Thermo Scientific™ 14503210	Pigeon feathers	Re215	10 Tests	ASR
14-503-310P	Thermo Scientific™ 14503310	Rabbit, serum proteins	Re206	10 Tests	ASR
14-515-710P	Thermo Scientific™ 14515710	Ferret epithelium	Re217	10 Tests	ASR
14-523-010P	Thermo Scientific™ 14523010	Chicken, serum proteins	Re219	10 Tests	ASR
14-522-910P	Thermo Scientific™ 14522910	Chicken droppings	Re218	10 Tests	ASR
14-416-801P	Thermo Scientific™ 14416801	Pigeon droppings	e7	16 Tests	FDA Cleared
14-501-610P	Thermo Scientific™ 14501610	Horse, serum proteins	Re205	10 Tests	ASR

Description

Quantify specific IgE antibodies with ImmunoCAP™ Epidermal and Animal Protein Allergens, essential tools to aid in the diagnosis of allergic conditions. IgE antibodies appear in human serum and plasma as a result of sensitization to a specific allergen. Measurement of circulating IgE antibodies provides an objective assessment of sensitization to an allergen. In general, low IgE antibody levels indicate a low probability of allergic disease, whereas high antibody levels to an allergen show a higher correlation with an allergic disease.

ImmunoCAP Specific IgE offers the laboratory:

• Truly quantitative measuring range from 0.1 to 100 kUA/L
• Intra-assay CV (%) comparable to routine clinical chemistry immunoassays
• Excellent consistency over time, and between countries, systems, labs and persons

Expected test values
ImmunoCAP Specific IgE detects IgE antibodies in the range 0.1 to 100 kUA /l, where A represents allergen-specific antibodies. The result is reported quantitatively. In clinical practice, 0.35 kUA /l has commonly been used as a cut-off. A large number of studies have been performed to evaluate the clinical performance of ImmunoCAP Specific IgE tests in allergy diagnosis. Clinical performance is expressed as sensitivity, ranging from 84 to 95%, and specificity, ranging from 85 to 94%. Sensitivity and specificity were reported from multi-center studies including several hundred patients tested for a range of different allergens.

• Specimen collection and preparation
• Use serum and plasma (EDTA or heparin) samples from venous or capillary blood
• Collect blood samples using standard procedures
• Keep specimens at room temperature (RT) for shipping purposes only
• Store at 2–8°C up to one week, otherwise store at –20°C
• Avoid repeated freezing and thawing

Note: Blood samples for testing ImmunoCAP drugs and venom should be collected during or close to the event, preferably not later than 6 months after exposure. If the test result is negative and an IgE-mediated reaction is still strongly suspected, it is advisable to draw a new sample and repeat the test at 5 to 6 weeks.

The presence of specific IgE antibodies is useful to identify the allergens that elicit symptoms and signs of allergy in patients with respiratory allergic diseases including asthma, food allergy, and anaphylactic sensitivity.

Knowing IgE antibody levels provides guidance to clinicians to:

• Identify offending allergens
• Tailor advice to individual patients
• Indicate development of tolerance (food allergy, specific immunotherapy)
• Inform optimized individual medical treatment plans
• Refer to specialists appropriately
• Evaluate whether or not specific immunotherapy is an option

Specific IgE testing also aids in the identification of patients at risk of:

• The allergy march – a progression of skin symptoms to respiratory symptoms
• Severe symptoms including asthma exacerbations – a progression of mild symptoms to severe symptoms
• Progression of recurrent symptoms to persistent symptoms

As in all diagnostic testing, a definitive clinical diagnosis should be made by the clinician after evaluation of all clinical and laboratory findings.

Specifications

• Code Type: Animal Protein