Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ Human Stem Cell Factor (SCF) Synthetic Peptide
Synthetic Peptide
Supplier: Invitrogen™ PEP0860
Description
SCF Synthetic Peptide, PEP-0860, from Invitrogen.
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist. This peptide corresponds to 18 amino acids near the center of human SCF.PEP-0860 can be used as a blocking peptide with polyclonal antibody PA5-20746.![TRUSTED_SUSTAINABILITY](/content/dam/fishersci/glyphs/Sustain_Badge.png)
Specifications
4254 | |
purified | |
Human Stem Cell Factor (SCF) | |
-20°C | |
Liquid | |
Blocking Assay, Control | |
No | |
Peptide | |
RUO - research use only |
Human | |
P21583 | |
200 μg/mL | |
Synthetic Peptide | |
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 | |
KITLG | |
0.02% sodium azide | |
50 μg | |
PBS |
Provide Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?
Provide Content Correction