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Invitrogen™ Human Estrogen Receptor alpha Synthetic Peptide

Synthetic Peptide

Supplier:  Invitrogen™ PEP1620

Catalog No. PEP1620


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Description

Description

ESR1 Synthetic Peptide, PEP-1620, from Invitrogen.

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. This peptide corresponds to 18 amino acids near the carboxy terminus of ESR1.PEP-1620 can be used as a blocking peptide with polyclonal antibody PA5-34577. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37°C.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

2099
purified
Human Estrogen Receptor alpha
-20°C
Liquid
Blocking Assay, Control
No
Peptide
RUO - research use only
Human
P03372
200 μg/mL
Synthetic Peptide
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
ESR1
0.02% sodium azide
50 μg
PBS
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