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BIORTUS USA INC Gene Name: DPP 8. Uniprot: Q6V1X1. Construct: DPP 8(M1-I898 end). Expression Host: Insect cell. Purity: 90%. 1 each contains 100UG.

Supplier:  BIORTUS USA INC BP0634300A

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Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8. Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation. The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition.

Catalog No. NC2953440


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