Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Azoles
  7. Isoxazoles
  8. GW 4064, Tocris Bioscience™

GW 4064, Tocris Bioscience™

Catalog Number 247350
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
278779-30-9
C28H22Cl3NO4
542.837
BYTNEISLBIENSA-MDZDMXLPSA-N
e-3-2-chloro-4-3-2,6-dichlorophenyl-5-isopropylisoxazol-4-yl methoxy styryl benzoic acid, unii-sr225wuz0h, sr225wuz0h, 3-2-2-chloro-4-3-2,6-dichlorophenyl-5-isopropylisoxazol-4-ylmethoxy phenyl vinyl benzoic acid, benzoic acid, 3-2-2-chloro-4-3-2,6-dichlorophenyl-5-1-methylethyl-4-isoxazolyl methoxy phenyl ethenyl, 3-2,6-dichlorophenyl-4-3'-carboxy-2-chlorostilben-4-yl oxymethyl-5-isopropylisoxazole, 3-e-2-2-chloro-4-3-2,6-dichlorophenyl-5-1-methylethyl isoxazol-4-yl methoxy phenyl ethenyl benzoic acid, 3-e-2-2-chloro-4-3-2,6-dichlorophenyl-5-propan-2-yl-1,2-oxazol-4-yl methoxy phenyl ethenyl benzoic acid, 3-2-2-chloro-4-3-2,6-dichlorophenyl-5-1-methylethyl-4-isoxazolyl methoxy phenyl ethenyl benzoic acid
9893571
CHEBI:79997
3-[(E)-2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]ethenyl]benzoic acid
CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)C=CC4=CC(=CC=C4)C(=O)O)Cl
This item is not returnable. View return policy
278779-30-9
C28H22Cl3NO4
542.837
BYTNEISLBIENSA-MDZDMXLPSA-N
e-3-2-chloro-4-3-2,6-dichlorophenyl-5-isopropylisoxazol-4-yl methoxy styryl benzoic acid, unii-sr225wuz0h, sr225wuz0h, 3-2-2-chloro-4-3-2,6-dichlorophenyl-5-isopropylisoxazol-4-ylmethoxy phenyl vinyl benzoic acid, benzoic acid, 3-2-2-chloro-4-3-2,6-dichlorophenyl-5-1-methylethyl-4-isoxazolyl methoxy phenyl ethenyl, 3-2,6-dichlorophenyl-4-3'-carboxy-2-chlorostilben-4-yl oxymethyl-5-isopropylisoxazole, 3-e-2-2-chloro-4-3-2,6-dichlorophenyl-5-1-methylethyl isoxazol-4-yl methoxy phenyl ethenyl benzoic acid, 3-e-2-2-chloro-4-3-2,6-dichlorophenyl-5-propan-2-yl-1,2-oxazol-4-yl methoxy phenyl ethenyl benzoic acid, 3-2-2-chloro-4-3-2,6-dichlorophenyl-5-1-methylethyl-4-isoxazolyl methoxy phenyl ethenyl benzoic acid
9893571
CHEBI:79997
3-[(E)-2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]ethenyl]benzoic acid
CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)C=CC4=CC(=CC=C4)C(=O)O)Cl

Description

Selective farnesoid X receptor (FXR) agonist

GW 4064 is a potent and selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). GW 4064 displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves hyperglycaemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutrient-deprived mouse hepatocytes. GW 4064 protects against lipopolysaccharide (LPS)-induced liver inflammation and apoptosis in mice. GW 4064 reduces Leptin signaling pathway activation in breast cancer cells and inhibits tumor growth in mouse xenografts.
Quantity 50 mg
Formula Weight 542.84
Percent Purity >97%
Chemical Name or Material GW 4064

Safety and Handling

Recommended Storage Desiccate at +4°C
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit