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Guanidine Hydrochloride, Ultra Pure grade, MP Biomedicals
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Quantity:
100 g
1 kg
Description
- Guanidine Hydrochloride is a strong chaotropic agent useful for the denaturation and subsequent refolding of proteins
- This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies
- This can be used as the first step in refolding proteins or enzymes into their active form
- Urea and dithiothreitol (DTT) may also be necessary
- Guanidine HCl is used in the isolation of RNA to dissociate the nucleoprotein into its nucleic acid and protein moieties
- It is an inhibitor of RNase
- Highly concentrated (6 - 8 M) Guanidine HCl solutions are used to denature native globular proteins
- It apparently disrupts hydrogen bonds which hold the protein in its unique structure; however, there also is evidence suggesting that guanidine hydrocholoride may disrupt hydrophobic interactions by promoting the solubility of hydrophobic residues in aqueous solutions
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Specifications
Melting Point | 180°C to 190°C |
Color | White |
Linear Formula | CH5N3·HCl |
Quantity | 1 kg |
Solubility Information | Soluble in water (6 M - clear, colorless solution). |
Formula Weight | 95.53 |
Percent Purity | ≥99% |
Grade | Ultra Pure |
Physical Form | Crystalline Powder |
Chemical Name or Material | GUANIDINE HYDROCHLORIDE |
Safety and Handling
Recommended Storage | Store at Room Temperature (15-30°C). Store Desiccated. |
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