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  7. Thermo Scientific Chemicals Guanidine hydrochloride, Molecular Biology Grade

Thermo Scientific Chemicals Guanidine hydrochloride, Molecular Biology Grade

Catalog Number AAJ6566122
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Quantity:
100 g
500 g
50-01-1
CH6ClN3
95.53
MFCD00013026
PJJJBBJSCAKJQF-UHFFFAOYSA-N
guanidine hydrochloride, guanidinium chloride, guanidine, monohydrochloride, aminoformamidine hydrochloride, aminomethanamidine hydrochloride, guanidine monohydrochloride, guanidine hcl, guanidine chloride, iminourea hydrochloride, carbamidine hydrochloride
5742
CHEBI:32735
guanidine;hydrochloride
C(=N)(N)N.Cl
50-01-1
CH6ClN3
95.53
MFCD00013026
PJJJBBJSCAKJQF-UHFFFAOYSA-N
guanidine hydrochloride, guanidinium chloride, guanidine, monohydrochloride, aminoformamidine hydrochloride, aminomethanamidine hydrochloride, guanidine monohydrochloride, guanidine hcl, guanidine chloride, iminourea hydrochloride, carbamidine hydrochloride
5742
CHEBI:32735
guanidine;hydrochloride
C(=N)(N)N.Cl

Description

A protein denaturant

Guanidine hydrochloride is used for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Guanidine hydrochloride is used for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.

Solubility
Freely soluble in water

Notes
Protect from heat. Store away from oxidizing agents.
TRUSTED_SUSTAINABILITY
Melting Point 178°C to 185°C
Color White
Density 1.34
Quantity 100 g
Beilstein 3591990
Sensitivity Hygroscopic
Merck Index 144562
Solubility Information Freely soluble in water
Formula Weight 95.53
Grade Molecular Biology
Physical Form Crystalline Solid
Chemical Name or Material Guanidine hydrochloride
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Safety and Handling

Hazard Category Serious eye damage/eye irritation (category 2), Skin corrosion/irritation (category 2), Acute toxicity (category 4)
Hazard Statement Causes serious eye irritation, May form combustible dust concentrations in air, Causes skin irritation, Harmful if swallowed or if inhaled
EINECSNumber 200-002-3
RTECSNumber MF4300000
TSCA Yes
Recommended Storage Ambient temperatures
SDS

RUO – Research Use Only

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