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  8. Thermo Scientific Chemicals Fluconazole, 98%

Thermo Scientific Chemicals Fluconazole, 98%

Catalog Number AC455480010
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Quantity:
1 g
5 g
86386-73-4
C13H12F2N6O
306.27
RFHAOTPXVQNOHP-UHFFFAOYSA-N
fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
3365
CHEBI:46081
2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
86386-73-4
C13H12F2N6O
306.27
RFHAOTPXVQNOHP-UHFFFAOYSA-N
fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
3365
CHEBI:46081
2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

Description

Fluconazole, 98%, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species

• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity

• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)

• Mammalian cell demethylation is much less susceptible to fluconazole inhibition

Applications

• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.

• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene

• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays

• It has also been used as a positive control in antifungal assay of plants

TRUSTED_SUSTAINABILITY
Melting Point 137.0°C to 141.0°C
Loss on Drying 1% max. (105°C, 3 h)
Infrared Spectrum Authentic
Assay Percent Range 97.5% min. (HPLC)
Packaging Glass Bottle
Quantity 1 g
Solubility Information Solubility in water: <1mg/mL at 25 deg c. Other solubilities: solubility in ethanol: 61mg/mL at 25 deg c, solubility in dmso: 61mg/mL at 25 deg c
Formula Weight 306.27
Percent Purity 98%
Chemical Name or Material Fluconazole

Safety and Handling

Hazard Category GHS Signal Word: Warning
Hazard Statement GHS H Statement
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May damage the unborn child.
Precautionary Statement GHS P Statement
IF ON SKIN: Wash with plenty of soap and water.
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses,if present and easy to do.
Continue rinsing.
IF INHALED: Remove to fresh air and kee
SDS

RUO – Research Use Only

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