Diclofenac sodium salt, Thermo Scientific Chemicals

Description

Standard NSAID and cyclooxygenase (COX) inhibitor

Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Oxidation of diclofenac sodium produces the metabolite 4′-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4′-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.

Solubility
Soluble in water (50 mg/ml), PBS pH 7.2 (6 mg/ml), ethanol (∼35 mg/ml), DMF (∼35 mg/ml), DMSO (∼35 mg/ml), methanol (>24 mg/ml), and acetone (6 mg/ml).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Specifications

• Melting Point: 283°C to 285°C
• Color: White
• Quantity: 25 g
• UN Number: UN2811
• Merck Index: 14,3081
• Solubility Information: Soluble in water to 50mg/ml.
• Formula Weight: 318.14
• Physical Form: Powder
• Chemical Name or Material: Diclofenac sodium salt

Safety and Handling

Hazard Category	H301
Hazard Statement	GHS H Statement H301-H361 Toxic if swallowed. Suspected of damaging fertility or the unborn child.
Precautionary Statement	P264b-P270-P301+P310-P330-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	239-346-4
RTECSNumber	AG6330000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only