Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Lactims
  7. 2397641GM

MilliporeSigma™ Cycloheximide, >98%, Calbiochem™

Click to view available options
Quantity:
1g
Packaging:
Alu drum
66-81-9
C15H23NO4
281.35
MFCD00082346
YPHMISFOHDHNIV-FSZOTQKASA-N
cycloheximide, actidione, cycloheximide, naramycin a, kaken, actidion, actidone, hizarocin, naramycin, neocycloheximide
6197
CHEBI:27641
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1
66-81-9
C15H23NO4
281.35
MFCD00082346
YPHMISFOHDHNIV-FSZOTQKASA-N
cycloheximide, actidione, cycloheximide, naramycin a, kaken, actidion, actidone, hizarocin, naramycin, neocycloheximide
6197
CHEBI:27641
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1

Description

Antifungal antibiotic. Inhibits protein synthesis in eukaryotes. Interacts directly with translocase and interferes with translocation step.

  • Antifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes
  • Interacts directly with translocase enzyme, interfering with the translocation step
  • Inhibits cell-free protein synthesis in eukaryotes
  • Competitively inhibits hFKBP12 (Ki = 3.4 μM)
  • Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages
  • Inhibits DNA cleavage in rat thymocytes treated with Thapsigargin, methylprednisolone, and Ionomycin
  • Rapidly destroyed in alkaline solutions.
  • Also available as a 300 mM solution in DMSO

Recommended Storage

+15°C to +30°C, Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.

Appearance White solid
Packaging Alu drum
Merck Index 14, 2728
Quantity 1g
Solubility Information Soluble in Chloroform, Ethanol, and Methanol
Physical Form White solid
Percent Purity ≥98%
Chemical Name or Material Cycloheximide, High Purity
Grade By HPLC

Safety and Handling

R: 28-40-51/53-61 Very toxic if swallowed. Limited evidence of a carcinogenic effect. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. May cause harm to the unborn child.

S: 45-53-61 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid exposure - obtain special instructions before use. Avoid release to the environment.

Highly Toxic & Carcinogenic / Teratogenic

RTECSNumber : MA4375000

storageNote1 : Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.

Recommended Storage : +15°C to +30°C; Ok to freeze;