Thermo Scientific Chemicals Chloroform, Molecular Biology Reagent

Description

Chloroform is a common laboratory reagent favored for use as a solvent due to the compounds relative unreactivity and miscibility with most organic compounds. Chloroform is also used in organic synthesis as a source for CCl2. In the swine tracheal smooth muscle, chloroform has been demonstrated to directly and in a concentration dependent manner induce contractions. It has been observed that Chloroform can release Ca2+ from ryanodine sensitive receptors in chloroform-induced contraction in swine tracheal smooth muscle. At concentrations of 100 and 250 ppm in mouse splenocyte, basal proliferation was increased yet a decrease in circulating neutrophils was documented.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Chloroform is a common laboratory reagent favored for use as a solvent due to the compounds relative unreactivity and miscibility with most organic compounds. Chloroform is also used in organic synthesis as a source for CCl2. In the swine tracheal smooth muscle, chloroform has been demonstrated to directly and in a concentration dependent manner induce contractions. It has been observed that Chloroform can release Ca2+ from ryanodine sensitive receptors in chloroform-induced contraction in swine tracheal smooth muscle. At concentrations of 100 and 250 ppm in mouse splenocyte, basal proliferation was increased yet a decrease in circulating neutrophils was documented.

Solubility
Soluble in water at 20°C 8 g/L.

Notes
Stabilized with approx. 50 ppm amylene

Specifications

• Melting Point: -63°C
• Color: Colorless
• UN Number: UN1888
• Beilstein: 1731042
• Merck Index: 14,2141
• Solubility Information: Soluble in water at 20°C 8g/L.
• IUPAC Name: chloroform
• Formula Weight: 119.38
• Density: 1.492 g/mL
• Boiling Point: 61°C
• Quantity: 500 mL
• Odor: Characteristic
• Physical Form: Liquid
• Refractive Index: 1.446
• Chemical Name or Material: Chloroform, Molecular Biology Reagent

Safety and Handling

GHS H Statement
H351-H373-H302-H315
Suspected of causing cancer.
May cause damage to organs through prolonged or repeated exposure.
Harmful if swallowed.
Causes skin irritation.

P201-P202-P260-P264b-P270-P271-P280i-P281-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P330-P332+P313-P362-P501c

H302-H315-H319-H331-H335-H336-H351-H361d-H373

DOTInformation : Transport Hazard Class: 6.1; Packaging Group: III; Proper Shipping Name: CHLOROFORM

EINECSNumber : 200-663-8

RTECSNumber : FS9100000

TSCA : Yes

Recommended Storage : Ambient temperatures

SDS

RUO – Research Use Only