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CD326 (Ep-CAM) Rat, anti-Mouse, RB780, Clone: G8.8, BD Horizon™
Rat Monoclonal Antibody
$130.00 - $322.00
Specifications
Antigen | CD326 (Ep-CAM) |
---|---|
Clone | G8.8 |
Concentration | 0.2 mg/mL |
Applications | Flow Cytometry |
Conjugate | RB780 |
Description
The G8.8 monoclonal antibody recognizes CD326/Ep-CAM (Epithelial Cell Adhesion Molecule), also known as gp40 in the mouse and by a variety of names (including GA733-2, CO17-1A, and EGP) in the human. In the mouse, Ep-CAM is a 40-42 kDa cell-surface type 1 transmembrane glycoprotein expressed on thymic epithelial cells, thymic dendritic cells, immature thymocytes, a small subset of peripheral T lymphocytes, intestinal epithelium, kidney-collecting tubule epithelium, keratinocytes, Langerhans cells and lymph node and splenic dendritic cells. Profiles of Ep-CAM expression on fetal thymocytes and on the CD4[-] CD8[-], CD4[+] CD8[+], CD4[-] CD8[+], and CD4[+] CD8[-] subsets of adult thymocytes have been published. In unrelated studies, mouse Ep-CAM mRNA was detected in tissues containing epithelial cells (kidney, stomach, intestine, lung, and thymus) and in plasma cells and plasmacytomas, but not in heart, muscle, liver, brain, spleen, B lymphomas, or pre-B lymphomas. Ep-CAM is a Ca[2+] independent homophilic adhesion molecule that is proposed to play roles in the development and normal function of epithelial tissues and in the progression of carcinomas.
Specifications
CD326 (Ep-CAM) | |
0.2 mg/mL | |
RB780 | |
RUO | |
Aqueous buffered solution containing ≤0.09% sodium azide | |
Glycoconjugates from BALB/c mouse-derived TE-71 medullary thymic epithelial cell line | |
Secondary |
G8.8 | |
Flow Cytometry | |
Rat | |
Mouse | |
17075 | |
IgG2a κ | |
Refrigerate (2°C to 8°C) |
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