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BD Horizon™ CD105 Mouse, anti-Human, RY586, Clone: 266, BD Horizon™

Mouse Monoclonal Antibody

$110.00 - $275.00

Specifications

Antigen CD105
Clone 266
Applications Flow Cytometry
Conjugate RY586
Host Species Mouse
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB568141
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BD Horizon™
568141
100 Tests
Each for $275.00
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BDB568142
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BD Horizon™
568142
25 Tests
Each for $110.00
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Description

Description

The 266 monoclonal antibody specifically binds to CD105. CD105 is a type I transmembrane glycoprotein that is encoded by END (Endoglin) and belongs to the transforming growth factor-β (TGF-β) type III receptor family. CD105 is expressed on cells as a homodimer comprised of ~95 kDa subunits. CD105 is expressed on vascular endothelial cells and placental syncytiotrophoblasts and at lower levels on stromal fibroblasts. It is also expressed on mesenchymal stem cells, erythroid precursors, activated macrophages, pre-B cells, and some tumor cells and cell lines including U937 cells. CD105 serves as a regulatory component of the TGF-β receptor system. In association with TGF- βRI or TGF- βRII, CD105 binds TGF-β1 and TGF-β3 with high affinity but does not bind to TGF-β2. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.

Specifications

Specifications

CD105
Flow Cytometry
Mouse
Human
266
RY586
RUO
Primary
SDS
Product Certifications
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