Thermo Scientific Chemicals Calpeptin, ≥98%

Description

Inhibitor of the calcium-dependent protease calpain and cathepsin L

Calpeptin is used to to inhibit the activities of cathepsin L and calpain-1. Calpeptin blocked the expression of aspartyl protease cathepsin D, amyloid precursor protein, and calparin. It acts as an inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. It is shown to preferentially inhibit a subset of protein-tyrosine phosphatases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Specifications

Chemical Identifiers

• CAS: 117591-20-5
• Molecular Formula: C₂₀H₃₀N₂O₄, C20H30N2O4
• Synonym: N-Benzyloxycarbonyl-L-leucyl-norleucinal; Z-Leu-norleucinal

• Quantity: 10 mg
• Description: White
• Content And Storage: -30°C to -10°C
• For Use With (Application): Inhibitor of the calcium-dependent protease calpain and cathepsin L
• Formula Weight: 362.50g/mol
• Solubility: Soluble in DMSO at 15mg/ml
• Product Type: Signal Transduction Reagent
• Form: Powder
• InChI Key: PGGUOGKHUUUWAF-ROUUACIJSA-N
• SMILES: CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1)C=O
• IUPAC Name: benzyl N-[(1S)-3-methyl-1-{[(2S)-1-oxohexan-2-yl]carbamoyl}butyl]carbamate
• Molecular Weight (g/mol): 362.47
• Assay: ≥98%

Safety and Handling

Recommended Storage

Store at -20°C

SDS

RUO – Research Use Only