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CACNG1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA5109283
Description
Positive Control: Human skeletal muscle tissue, mouse skeletal muscle tissue, rat skeletal muscle tissue, SH-SY-5Y.
Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an alpha1 subunit, a beta subunit, a gamma subunit and an alpha2 delta subunit. The beta subunit is encoded by four genes, designated beta1-beta4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the alpha1 subunit. L-type Ca ++ CP gamma1, also known as CACNLG or CACNG1, is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, L-type Ca ++ CP gamma1 is a subunit of the dihydropyridine (DHP) sensitive calcium channel and may play a role in excitation-contraction coupling. L-type Ca++ CP gamma1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly used inhalation anesthetics and depolarizing muscle relaxants.![TRUSTED_SUSTAINABILITY](/content/dam/fishersci/glyphs/Sustain_Badge.png)
Specifications
CACNG1 | |
Polyclonal | |
Unconjugated | |
Cacng1 | |
Cacng; Cacng1; CACNLG; calcium channel, voltage-dependent, gamma subunit 1; calcium voltage-gated channel auxiliary subunit gamma 1; dihydropyridine receptor gamma 1; dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma; L-type calcium channel gamma polypeptide; neuronal dihydropyridine-sensitive calcium channel gamma subunit; voltage-dependent calcium channel gamma-1 subunit | |
Rabbit | |
Affinity chromatography | |
RUO | |
12299, 786 | |
-20° C, Avoid Freeze/Thaw Cycles, store in dark | |
Liquid |
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4 | |
O70578, Q06432 | |
Cacng1 | |
Synthetic peptide within mouse CACNG1 aa 13-62 | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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